Table 4 |
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|
Effect of the APOE ε4 allele on age at onset in LOAD and EOAD |
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|
Number of APOE ε4-alleles |
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|
|
||||||
|
0 |
1 |
2 |
||||
|
|
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|
EOAD. Age at onset ± SD, n |
57.3 ± 4.0 |
14 |
57.3 ± 4.7 |
16 |
58.7 ± 2.6 |
10 |
|
LOAD. Age at onset ± SD, n |
78.4 ± 5.8 |
121 |
75.3 ± 5.8a |
168 |
72.9 ± 5.0b |
47 |
|
|
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|
SD = Standard deviation n = number of patients EOAD: Early onset Alzheimer's disease (onset < 65 years), no significant difference in onset between carriers of none, one and two APOE ε4 alleles. LOAD: Late onset Alzheimer's disease (onset ≥ 65 years) a: The difference between onset in LOAD (Late Onset AD) in carriers of none and one APOE ε4 allele was significant; p = 0.005. b: The difference between onset in LOAD in carriers of one and two APOE ε4 alleles was significant; p = 0.002. |
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|
Sando et al. BMC Neurology 2008 8:9 doi:10.1186/1471-2377-8-9 |
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