Figure 3.

The neuropathology of case III:12. (A) C7 cervical cord showing symmetrical Wallerian degeneration of lateral corticospinal tracts and anterior corticospinal tract. Note atrophy of anterior nerve roots in comparison to dorsal nerve roots. TDP-43 immunopositive skein-like (B) and punctate (C) cytoplasmic inclusions within anterior horn cells of the spinal cord. (D) Normal TDP-43 positive nuclear staining of the anterior horn cell. (E) Anterior horn cell showing Bunina bodies. (F) Spongiosis in layers 2 and 3 of parasagittal motor cortex. (G) Residual Betz cell in motor cortex. Bar = 10 μm in B, C, D, E and G; 20 μm in F.

Luty et al. BMC Neurology 2008 8:32   doi:10.1186/1471-2377-8-32
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