Table 3

Regression Coefficients Expressing Cognitive Function Decrements (in SD units) for Each 10 Percentage Point Increment in 10-Year Risk of Stroke*

Unadjusted models

Fully adjusted models†

Cognitive Domain

β

(95% CI)

P

β

(95% CI)

P

Time orientation

-0.131

(-0.160 – -0.103)

< 0.001

-0.022

(-0.058 – 0.014)

0.231

Immediate verbal memory

-0.332

(-0.360 – -0.305)

< 0.001

-0.037

(-0.073 – -0.001)

0.044

Delayed verbal memory

-0.355

(-0.381 – -0.329)

< 0.001

-0.064

(-0.097 – -0.032)

< 0.001

Prospective memory

-0.244

(-0.267 – -0.221)

< 0.001

-0.026

(-0.059 – 0.007)

0.127

Semantic verbal fluency

-0.276

(-0.300 – -0.252)

< 0.001

-0.032

(-0.063 – -0.002)

0.038

Processing speed

-0.185

(-0.212 – -0.157)

< 0.001

-0.045

(-0.084 – -0.007)

0.022

Attention

-0.167

(-0.194 – -0.141)

< 0.001

-0.015

(-0.053 – 0.024)

0.449

Numeracy

-0.181

(-0.206 – -0.157)

< 0.001

-0.007

(-0.040 – 0.026)

0.683

Pooled data are shown as sex-specific analyses gave similar results. Persons with a history of stroke or dementia were excluded.

*Modified Framingham Stroke Risk Profile excluding left ventricular hypertrophy.

†Adjusted for age, sex, testing interval, education, socioeconomic status, total net non-housing wealth, BMI, alcohol consumption, and depressive symptoms.

Llewellyn et al. BMC Neurology 2008 8:12   doi:10.1186/1471-2377-8-12