Figure 4.

Active and total MMP-9 levels after 48 hours of ex-vivo doxycycline treatment. AVM-I: Doxycycline 10 μg/ml and 100 μg/ml significantly decreased active MMP-9 There was a significant reduction of total MMP-9 by doxycycline at 10 and 100 μg/ml There was no difference in active MMP-9 and total MMP-9 between doxycycline at 10 μg/ml and 100 μg/ml. AVM-II: Doxycycline 10 μg/ml significantly decreased active and total MMP-9. There was a trend for doxycycline 1 and 5 μg/ml to decrease active and total MMP-9. (mean ± SD)