Comments(1)

Tissue inhibitor of matrix metalloproteinase may also be involved.

Melvin Hayden   (24 January 2005)  Department of Family and Community Medicine University of Missouri School of Medicine

First congratualtions on your exciting study and findings!

Did you evaluate the levels of TIMP-4 in these studies?

We have been able to demonstrate a decrease in TIMP-4 in ischemic hearts (with left anterior decending coronary ligation) and furthermore we found that doxycycline ameliorated this decrease.

Since there is a delicate balance between TIMP-4 and MMP-9 it would be quite interesting to know the findings of TIMP-4

Reference

Camp TM, Tyagi SC, Aru GM, Hayden MR, Mehta JL, Tyagi SC: Doxycycline ameliorates ischemic and border-zone remodeling and endothelial dysfunction after myocardial infarction in rats.

J Heart Lung Transplant. 2004;23(6):729-36

I look forward to your comments regarding the above.

Sincerely,

M.R. (Pete) Hayden, M.D. ABPF / FAAFP

Adjunct Assistant Professor

Department of Family and Community Medicine

University of Missouri School of Medicine

Competing interests

NONE

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