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Open Access Research article

Card-placing test in amnestic mild cognitive impairment and its neural correlates

Seong-Joon Lee1, Young-Sil An2, Tae Sung Lim1 and So Young Moon1*

Author Affiliations

1 Department of Neurology, School of Medicine, Ajou University, 5 San, Woncheon-dong, Yongtong-gu, Suwon-si, Kyunggi-do 442-749, Republic of Korea

2 Nuclear Medicine, Ajou University School of Medicine, Suwon, Republic of Korea

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BMC Neurology 2014, 14:123  doi:10.1186/1471-2377-14-123

Published: 6 June 2014



We investigated anatomical correlates of the card-placing test (CPT) in patients with amnestic mild cognitive impairment (aMCI).


Fifteen aMCI patients underwent part A and part B of the CPT and FDG-PET. The CPT scores and MMSE scores of 29 cognitively normal people were used for comparison. Statistical parametric mapping (SPM) correlation analysis was used to extract the regions whose changes in regional cerebral metabolism correlated significantly with part A and B of the CPT with adjustment of age, education and sex of patients.


The aMCI patients had significantly lower MMSE scores (26.0 ± 2.0 vs. 28.2 ± 1.4, p < 0.001), CPT A (25.5 ± 3.5 vs. 27.7 ± 2.7, p = 0.026) and CPT B scores (16.3 ± 4.4 vs. 19.7 ± 3.7, p = 0.011) compared to the normal population. The test scores of part B of the CPT correlated well with hypometabolism of the posterior cingulate gyrus and precuneus.


This study suggests that the CPT B may reflect the functional status of the posterior cingulate gyrus in patients with aMCI.

Mild cognitive impairment; Heading disorientation; Posterior cingulate gyrus; Card placing test