Table 1

Effect of PPARGC1A rs3736265 on AO
rs3736265 genotype P1 P2
CC CT TT
All
N 1518 186 2
HD CAG repeat size 44.7 (4.6) 44.7 (3.8) 46.0 (2.8) n.s. n.s.
non-HD CAG repeat size 18.5 (3.4) 18.5 (3.3) 19.0 (2.8) n.s. n.s
CAG-product3 828 (178) 831 (185) 870 (76) n.s. n.s.
Log AO4 1.641 (0.128) 1.627 (0.126) 1.601 (0.088) 0.0519 0.0170
AO5 43.75 42.36 39.9
Men
N 784 84 1
HD CAG repeat size 44.8 (4.5) 44.5 (.2) 44.0 (0) n.s. n.s.
non-HD CAG repeat size 18.6 (3.5) 18.8 (3.5) 21.0 (0) n.s. n.s
CAG-product3 836 (185) 840 (176) 924 (0) n.s. n.s.
Log AO4 1.655 (0.128) 1.629 (0.126) 1.638 (0) 0.0164 0.0042
AO5 45.19 42.56 43.45
Women
N 734 102 1
HD CAG repeat size 44.5 (4.7) 44.8 (4.2) 48.0 (0) n.s. n.s.
non-HD CAG repeat size 18.4 (3.4) 18.3 (3.2) 17.0 (0) n.s. n.s.
CAG-product3 818 (170) 823 (192) 816 n.s. n.s.
Log AO4 1.626 (0.128) 1.622 (0.127) 1.568 (0) 0.6732 0.5705
AO5 42.27 41.88 36.98

Data are means (SD); P1, additive model; P2, dominant model; ANOVA; 3product of the CAG sizes in the two alleles 4adjusted for HD CAG and non-HD CAG sizes and their products. 5ANOVA was used and the p-values refer to the log-transformed age-at-onset. The age-at-onset is only shown to give an estimate of the effects that is easier to interpret. All genotype distributions are in HW equilibrium, MAF in entire population 0.0554.

Weydt et al.

Weydt et al. BMC Neurology 2014 14:1   doi:10.1186/1471-2377-14-1

Open Data