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Open Access Research article

The association between oxcarbazepine-induced maculopapular eruption and HLA-B alleles in a Northern Han Chinese population

Yu-Dan Lv1, Fu-Li Min2, Wei-Ping Liao2, Na He2, Tao Zeng2, Di-Hui Ma1* and Yi-Wu Shi2*

Author Affiliations

1 Department of Neurology, The First Affiliated Hospital of Jilin University, 71 Xinmin Street, Chang Chun, P. R. China

2 Institute of Neuroscience and Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China

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BMC Neurology 2013, 13:75  doi:10.1186/1471-2377-13-75

Published: 8 July 2013

Abstract

Background

We investigated the association between oxcarbazepine (OXC)-induced maculopapular eruption (MPE) and HLA-B alleles in a northern Han Chinese population, and conducted an analysis of clinical risk factors for OXC-MPE.

Methods

Forty-two northern Han Chinese patients who had been treated with OXC in Changchun, China were genotyped. Among them were 14 cases with OXC-induced MPE; the remaining 28 were OXC-tolerant. The HLA-B allele frequencies of the normal control group were found in the Allele Frequency Net Database. Polymerase chain reaction-sequence specific primer( PCR-SSP )was used for HLA-B*1502 testing and direct sequencing for four-digit genotype determination.

Results

Four-digit allele sequencing showed that there was no statistically significant difference in the frequency of the HLA-B*1502 allele between the OXC-MPE and OXC-tolerant controls (3.6% versus 7.5%, OR = 0.38, 95% CI = 0.04–3.40, P = 0.65), as well as between OXC-MPE and normal controls (3.6% versus 2.4%, OR = 1.54, 95% CI = 0.20–11.73, P = 0.49). However, a significant difference in the frequency of HLA-B*3802 alleles was found between the MPE group and normal controls (10.7% versus 1.9%, OR = 6.329, 95% CI = 1.783-22.460, P = 0.018). There was no significant difference in terms of age, gender, or final OXC dose between the OXC-MPE and OXC-tolerant groups.

Conclusions

There was no significant association between OXC-MPE and HLA-B*1502 in the northern Han Chinese population in our study. Instead, HLA-B*3802 was found to be a potential risk factor for OXC-MPE.

Keywords:
Mild maculopapular eruption; HLA-B* 1502; Northern Han Chinese; DNA genotyping