Table 2

Clinical and Laboratory results a
Study group Low dose group High dose group
800 IU/day 4370 IU/day
Parameter Baseline 3Months 6 Months End p-value Baseline 3Months 6 Months End p-value
Annual Relapse rate 0.38±0.26 -- -- 0.34±0.27 0.88 b 0.28±0.23 -- -- 0.51±0.34 0.32 b
EDSS 3.6±2.2 -- 3.6±2.1 3.6±2.3 0.1c 2.9±2.0 -- 3.4±2.3 3.3±2.4 0.26 c
4.5 2.8 3.0 2.5 3 2.5
(0-7) (0-7) (0-7) (0-7) (0-7) (0-7)
Quality of life score (FAMS) 145.6±30.8 -- -- 142.7±32.5 0.68 d 147.9±38.6 -- -- 146.6±45.5 0.84 d
138 134 158 150
(103-205) (94-212) (85-211) (71-225)
Serum calcium (mg/dl) 9.5±0.4 9.7±0.3 9.5±0.4 9.5±0.5 0.4 c 9.6±0.3 9.7±0.2 9.6±0.2 9.4±0.5 0.2 c
9.5 9.6 9.5 9.4 9.5 9.5 9.6 9.4
(8.7-10.2) (9.2-10.2) (9-10.3) (8.9-10.3) (9.2-10.1) (9.4-10.1) (9.2-10.1) (8.6-10.1)
PTH (pg/ml) 36.7 ±17.1 31.6±11.5 -- -- 0.17 d 30.4±13.5 25.0±10.0 -- -- 0.04 d
35.5 29.4 31.1 21.7
(11.5-77.4) (12.8-53.3) (8.3-49.9) (6.4-41.4)
IFN-γ (pg/ml) 0.20±0.22 0.14±0.2 -- -- 0.13 d 0.51±1.1 0.58±1.3 -- -- 0.7 d
0.08 0.03 0.05 0.07
(0-0.61) (0-0.77) (0-4.4) (0-5.8)
IL17 (pg/ml) 4.01±3.99 9.14±9.9 -- -- 0.04 d 5.83±6.1 6.38±6.7 -- -- 0.75 d
3.74 7.8 4.3 3.4
(0-11) (0-38.3) (0-19) (0-20.8)
IL10 (pg/ml) undetected undetected -- -- -- undetected undetected -- -- --

a. Summary statistics are mean ± standard deviation and median (range).

b. Mid-P exact test.

c. ANOVA with repeated measures.

d. Paired Student’s t-test.

Golan et al.

Golan et al. BMC Neurology 2013 13:60   doi:10.1186/1471-2377-13-60

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