Table 2

Epidemiological features of selected studies
Study population Study period Study Sex- and age-specific counts Diagnostic criteria Other relevant information Data obtained from author or external sources (yes/no) F/M ratio (incident cases) Criteria fulfilled for inclusion in incidence, by age and sex, trend, both or none
First author and reference Number of years and intervals Number of cases (period) Diagnostic delay (DD) in years
Mean age at onset/diagnosis
1 Faroe Islands 1943-2007 81 NO <1986 Poser CD,CPr Mean age at onset NO 1.25 Trend
Denmark 65 >1986 Poser, 32y
Joensen 2011 [19] 7 McDonald and Thompson
2 South-west Sardinia 1958-2007 YES McDonald - NO None
Italy 50
Cocco 2011 [33] 5
3 Iceland 2002-2007 136 YES Poser CD for Mean age at diagnosis 36.3y YES 3 None
Eliasdottir 2011 [46] 6 PPMS Mean age at onset 32y
1
4 Oppland 1989-2001 148 NO Poser D and Pr, otherwise NS - NO 2.02 Trend
Norway 13
Risberg 2011 [55] 3
5 Faroe Islands 1986-2007 43 YES Poser and/or McDonald, for PPMS 36y at onset NO 1.53 Age- and sex-specific incidence
Denmark 22
Joensen 2010 [40] 1
6 Ostrobothnia 1992-2007 374 NO Poser CD Mean age at onset 31.7y NO None
Finland 16 McDonald CD Mean age at diagnosis 35.9y
Krokki 2010 [24] 1
7 Catania 1975-2004 367 (75-04) YES Poser CD,Cpr,LSPr Mean DD 1.4y NO 1.55 Both
Italy 30 108 (00-04) Age at onset increasing with time
Nicoletti 2011 [10] 6
8 Cardiff (Wales) 1985-2007 582 NO Poser and McDonald - NO 2.83 None
United Kingdom 23 (otherwise NS)
Hirst 2009 [38] 1
9 West Indies 1992-2007 130 YES Revised McDonald Mean age at onset 34.2y YES 4.2 Both
France 15
Cabre 2009 [8] 3
10 San Marino 1990-2005 33 YES Poser D,Pr Mean DD decreasing with time (1.5 to 0.08y) YES 3.12 Age- and sex-specific incidence
Italy 16
Granieri 2008 [35] 1
11 Greece 3 regions 1984-2006 834 NO Poser and McDonald D Mean DD 2.62y decreasing with time (3.23 to 1.79y) NO 1.38 None
Papathanasopoulos 2008 [60] 23 (otherwise NS) Mean age at onset 31.41y
4
12 Ferrara 1965-2003 200 (90-03) YES Poser CD,CP Mean DD decreasing with time (1.25 to 0.5y) YES 2.21 Both
Italy 39 421 (65-03)
Granieri 2007 [34] 4
13 UK cohort 1993-2000 642 YES Poser D,Pr, - NO 2.24 Age- and sex-specific incidence
Alonso 2007 [48] 8 McDonald D,Pr
1
14 Lorraine 1990-2002 1658 YES Poser D,Pr - YES 2.45 Both
France 13
Debouverie 2007 [31] 1
15 Hordaland 1953-2002 878 NO Poser Mean DD decreasing with time (9.8-0.9y) NO 1.9 Trend
Norway 50
Grytten 2006 [51] 10
16 Nordland 1970-1999 259 (70-99) YES Poser Mean DD 4.7y YES 1.87 None
Norway 30 183 (85-99) CDPr,,LSDPr Mean age at diagnosis 39y
Alstadhaug 2005 [30] 6
17 Catania 1975-1999 155 (90-99) YES Poser CDPr,LSDPr Mean at onset 33.3y YES 1.77 Both
Italy 25 Mean DD 1.7y
Nicoletti 2005 [32] 5
18 Sassari 1965-1999 689 NO Poser DD range 13.0-0.9y decreasing with time NO 2.57 Trend
Italy 34 Age at onset increasing with time
Pugliatti 2005 [54] 7
19 Monreale City 1981-2000 19 YES Poser D,Pr Mean DD 9.2y NO - Trend
Italy 20
Ragonese 2004 [41] 2
20 Evros 1974-1999 56 NO Poser CD,LSD - NO 2.8 Trend
Greece 26
Piperidou 2003 [53] 5
21 Vasterbotten County 1988-1997 133 YES Poser - NO 1.83 Age- and sex-specific incidence
Sweden 10
Sundström 2003 [37] 1
22 Finland 3 districts 1979-1993 1066 NO Poser CD or Lublin et al for PPMS Mean age at diagnosis for districts (35.7,39.3,39.7y) NO 1.6 None
Sumelahti 2003 [59] 15
2
23 Lower (Bajo) Aragon 1985-2002 42 NO Poser CD,CPr DD 2y NO 1.93 Trend
Spain 18 Mean age at onset 29y
Modrego 2003 [58] 1
24 Padova 1980-2000 580 NO Poser Decreasing DD with time NO 1.92 Trend
Italy 20 34y
Ranzato 2003 [28] 4
25 Iceland 1951-1999 372 NO Poser - NO 1.9 Trend
Benedikz 2002 [49] 49
10
26 Faroe Islands 1943-1994 54 NO Poser CD,CPr Individual age at onset available NO - Trend
Denmark 52
Kurtzke 2001 [21] 8
27 Enna, Sicily 1986-1995 16 YES Poser Mean DD 3y NO 1.28 None
Italy 10
Grimaldi 2001 [39] 1
28 Oslo 1972-1996 794 NO Poser CD For persons diagnosed 1986-1999 NO 2.38 None
Norway 25 DD 5.2y
Celius 2001 [26] 5 Age at diagnosis 38.1y
29 Nuoro 1955-1995 469 YES Poser (unspecified), Allison & Millar and Schumacher Mean DD 4.61y NO 1.95 Trend
Italy 41 Mean age at onset 28.5y
Granieri 2000 [27] 8
30 Alcoi 1986-1997 45 NO Poser CD,CPr - NO 4 Trend
Spain 12 Mean age at onset 35.1y
Mallada 2000 [57] 1
31 Troms & Finnmark 1974-1992 139 NO Rose DPrPs & Mean DD 4.5y NO 1.36 Trend
Norway 19 Poser CD,CPr,LSD Mean age at onset/diagnosis available
Gronlie 2000 [50] 4
32 Bagueria city 1985-1994 20 YES Poser Age at diagnosis 34.6y NO 1.86 None
Italy 10 Mean DD 2.6y
Salemi 2000 [42] 1
33 North-western Sardinia 1962-1991 277 YES Poser CD,CPr,LSD,LSPr DD range 8.0-1.8y decreasing with time NO 2.46 Trend
Italy 30 Mean age at onset 27y
Rosati 1996 [56] 6
34 Ferrara 1965-1993 252 YES Poser CD,CPr DD range 6.1-1.9y decreasing with time NO 2.07 Trend
Italy 29 Mean age at onset for specific forms
Granieri 1996 [43] 6
35 More & Romsdal 1950-1991 330 NO McAlpine DD potentially available 6y NO 1.41 Trend
Norway 42 39.2y
Midgard 1996 [52] 8
36 Reggio Emilia & Modena 1970-1990 316 (70-90) YES McAlpine CD,CPr - YES 2.01 Both
Italy 6 105 (85-90) Mean age at onset 30.75y
Guidetti 1995 [36] 4
37 Modena 1970-1990 183 (70-90) YES McAlpine D,Pr - YES 1.9 Both
Italy 6 59 (85-90) Mean age at onset 30.8y
Cavalletti 1994 [47] 4

Alcalde-Cabero et al.

Alcalde-Cabero et al. BMC Neurology 2013 13:58   doi:10.1186/1471-2377-13-58

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