Table 4

Frequency of tangle pathology scores for ApoE ϵ4 carriers and non-carriers by age group
Age group ≤69 70 - 79 80 - 89 ≥90
ϵ4+ ϵ4 - ϵ4+ ϵ4 - ϵ4+ ϵ4 - ϵ4+ ϵ4 -
Frontal Tangle Density None 1 (2.6%) 0 (0%) 14 (10.2%) 11 (8%) 20 (7.1%) 36 (12.9%) 6 (5.9%) 19 (18.6%)
Sparse 1 (2.6%) 0 (0%) 13 (9.4%) 8 (6%) 31 (11.1%) 36 (12.9%) 10 (9.8%) 21 (20.6%)
Moderate 0 (0%) 0 (0%) 8 (5.8%) 5 (3.6%) 27 (9.6%) 10 (3.6%) 6 (5.9%) 10 (9.8%)
Frequent 21 (53.9%) 16 (41.3%) 56 (40.9%) 23 (16.7%) 74 (26.4%) 46 (16.4%) 18 (17.7%) 12 (11.8%)
p = 0.23 p = 0.14 p = 0.001 p = 0.006
Temporal Tangle Density None 1 (2.6%) 0 (0%) 8 (5.8%) 8 (5.8%) 9 (3.2%) 13 (4.6%) 1 (1%) 8 (7.9%)
Sparse 1 (2.6%) 0 (0%) 9 (6.5%) 7 (5.1%) 12 (4.3%) 30 (10.7%) 9 (8.9%) 15 (14.9%)
Moderate 0 (0%) 0 (0%) 10 (7.3%) 4 (2.9%) 14 (5%) 20 (7.1%) 3 (3%) 12 (11.9%)
Frequent 21 (53.9%) 16 (41.3%) 64 (46.4%) 28 (20.3%) 118 (42.1%) 64 (22.9%) 27 (26.7%) 26 (25.7%)
p = 0.46 p = 0.13 p < 0.001 p = 0.02
Parietal Tangle Density None 2 (5.1%) 0 (0%) 16 (11.7%) 12 (8.8%) 18 (6.5%) 42 (15.1%) 8 (8.1%) 20 (20.2%)
Sparse 0 (0%) 0 (0%) 9 (6.6%) 6 (4.4%) 30 (10.8%) 25 (9%) 10 (10.1%) 18 (18.2%)
Moderate 1 (2.6%) 1 (2.6%) 6 (4.4%) 4 (2.9%) 27 (9.7%) 13 (4.7%) 6 (6.1%) 9 (9.1%)
Frequent 20 (51.3%) 15 (38.5%) 60 (43.8%) 24 (17.5%) 76 (27.2%) 48 (17.2%) 16 (16.2%) 12 (12.1%)
p = 0.23 p = 0.12 p < 0.001 p = 0.03
Hippocampal Tangle Density None 1 (2.6%) 0 (0%) 3 (2.2%) 5 (3.6%) 1 (0.4%) 6 (2.2%) 0 (0%) 3 (3%)
Sparse 1 (2.6%) 0 (0%) 3 (2.2%) 8 (5.8%) 7 (2.5%) 11 (4%) 2 (2%) 9 (9%)
Moderate 0 (0%) 0 (0%) 6 (4.3%) 5 (3.6%) 13 (4.7%) 21 (7.6%) 0 (0%) 7 (7%)
Frequent 21 (53.9%) 16 (41%) 80 (57.6%) 29 (20.9%) 130 (46.8%) 89 (32%) 28 (38%) 41 (41%)
p = 0.23 p < 0.001 p = 0.001 p = 0.002
Entorhinal Tangle Density None 0 (0%) 0 (0%) 1 (0.7%) 1 (0.7%) 0 (0%) 1 (0.4%) 0 (0%) 0 (0%)
Sparse 1 (2.6%) 0 (0%) 1 (0.7%) 4 (2.8%) 1 (0.4%) 6 (2.2%) 0 (0%) 1 (1%)
Moderate 1 (2.6%) 0 (0%) 5 (3.6%) 3 (2.2%) 3 (1.1%) 16 (5.8%) 1 (1%) 10 (10%)
Frequent 21 (53.9%) 16 (41%) 85 (61.2%) 39 (28.1%) 147 (53.1%) 103 (45.5%) 38 (38%) 50 (50%)
p = 0.23 p = 0.08 p < 0.001 p = 0.02

n (% = percent).

Sabbagh et al.

Sabbagh et al. BMC Neurology 2013 13:44   doi:10.1186/1471-2377-13-44

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