Table 3

Frequency of plaque pathology scores for ApoE ϵ4 carriers and non-carriers by age group
Age group ≤69 70 - 79 80 - 89 ≥90
ϵ4+ ϵ4 - ϵ4+ ϵ4 - ϵ4+ ϵ4 - ϵ4+ ϵ4 -
Frontal Plaque Density None 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 1 (1%)
Sparse 0 (0%) 0 (0%) 1 (0.7%) 1 (0.7%) 0 (0%) 3 (1.1%) 0 (0%) 1 (1%)
Moderate 2 (5.1%) 1 (2.6%) 5 (3.6%) 8 (5.8%) 5 (1.8%) 13 (4.6%) 2 (2%) 11 (10.8%)
Frequent 21 (58.9%) 15 (38.5%) 86 (61.87%) 38 (27.3%) 147 (52.5%) 112 (40%) 38 (37.3%) 49 (48%)
p = 0.78 p = 0.03 p = 0.003 p = 0.03
Temporal Plaque Density None 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%)
Sparse 0 (0%) 0 (0%) 0 (0%) 2 (1.4%) 0 (0%) 3 (1.1%) 0 (0%) 2 (2%)
Moderate 1 (2.6%) 0 (0%) 7 (5.0%) 6 (4.3%) 7 (2.5%) 21 (7.5%) 2 (2%) 8 (7.9%)
Frequent 22 (56.4%) 16 (41.0%) 85 (61.2%) 39 (28.1%) 146 (52.1%) 103 (36.8%) 38 (37.6%) 51 (50.5%)
p = 0.40 p = 0.08 p < 0.001 p = 0.08
Parietal Plaque Density None 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 2 (2%)
Sparse 0 (0%) 0 (0%) 0 (0%) 1 (0.7%) 0 (0%) 1 (0.4%) 0 (0%) 1 (1%)
Moderate 0 (0%) 0 (0%) 5 (3.6%) 6 (4.4%) 3 (1.1%) 14 (5%) 1 (1%) 7 (7%)
Frequent 23 (59%) 16 (41%) 87 (63%) 39 (28.3%) 148 (53.1%) 113 (40.5%) 39 (39%) 50 (50%)
p = 0.99 p = 0.05 p = 0.001 p = 0.03
Hippocampal Plaque Density None 0 (0%) 0 (0%) 2 (1.5%) 7 (5.1%) 3 (1.1%) 11 (3.9%) 0 (0%) 8 (8%)
Sparse 3 (7.7%) 1 (2.6%) 5 (3.6%) 6 (4.4%) 18 (6.4%) 38 (13.6%) 9 (9%) 15 (15%)
Moderate 4 (10.3%) 6 (15.4%) 44 (31.9%) 18 (13%) 70 (25%) 41 (14.6%) 15 (15%) 23 (23%)
Frequent 16 (41%) 9 (23.1%) 40 (29%) 16 (11.6%) 62 (22.1%) 37 (13.2%) 16 (16%) 14 (14%)
p = 0.56 p = 0.03 p < 0.001 p = 0.02
Entorhinal Plaque Density None 0 (0%) 0 (0%) 1 (0.7%) 4 (2.9%) 2 (0.7%) 2 (0.7%) 1 (1%) 3 (3%)
Sparse 0 (0%) 0 (0%) 1 (0.7%) 5 (3.6%) 3 (1.1%) 13 (4.6%) 1 (1%) 1 (1%)
Moderate 2 (5.1%) 2 (5.1%) 22 (15.8%) 14 (10.1%) 38 (13.6%) 39 (13.9%) 9 (8.9%) 24 (23.8%)
Frequent 21 (53.9%) 14 (35.9%) 68 (48.9%) 24 (17.3%) 110 (39.3%) 73 (26.1%) 29 (28.7%) 33 (32.7%)
p = 0.70 p = 0.002 p = 0.005 p = 0.08

n (% = percent).

Sabbagh et al.

Sabbagh et al. BMC Neurology 2013 13:44   doi:10.1186/1471-2377-13-44

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