Table 2

Sensitivity, specificity, and odds ratios of single colour Doppler sonography criteria in MS patients and HCs
Sensitivity, % (95% CI) Specificity, % (95% CI) Odds ratio, (95% CI)
Reflux of the IJV and/or VV (Cr 1) 63,0 78,9 6,4
(55,0-70,5) (64,2-89,5) (2,7-14,9)
Intracranial reflux (Cr 2) 28,1 84,2 2,1
(21,3-35,8) (70,3-93,1) (0,8-5,4)
IJV stenosis B-mode anomalies (Cr 3) 80,8 52,6 4,7
(73,9-86,6) (37,1-67,8) (2,2-10,0)
No flow in the IJV and/or VV (Cr 4) 26,7 97,4 13,5
(20,0-34,3) (88,4-99,6) (1,8-101,6)
Negative CSA (Cr 5) 6,2 97,4 2,4
(3,1-10,9) (88,4-99,6) (0,3-19,8)
CCSVI 76,0 84,2 16,9
(68,6-82,4) (70,3-93,1) (6,5-43,8)

An odds ratio greater than 1.0 indicates an increased likelihood of a diagnosis of CCSVI in MS patients versus controls.

Abbreviations: MS: multiple sclerosis; HCs: healthy controls; CCSVI: chronic cerebrospinal venous insufficiency; Cr: criterion; IJV: internal jugular vein; VV: vertebral vein; CSA: cross sectional area; CI: confidence interval.

Lanzillo et al.

Lanzillo et al. BMC Neurology 2013 13:20   doi:10.1186/1471-2377-13-20

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