Table 3

Included biomarkers in the project categorized by reflecting Aβ or neuronal injury
Technique Aβ accumulation Neuronal dysfunction
CSF Amyloid β42 in the CSF total tau and phosphorylated-tau in CSF
PET amyloid tracer uptake in PET fluorodeoxyglucose PET
MRI White matter integrity (DTI)
Functional connectivity (rsfMRI)
Whole brain volume
Hippocampal volume

Abbreviations: Aβ, beta-amyloid protein; CSF, cerebrospinal fluid; DTI, diffusion tensor imaging; MRI, magnetic resonance imaging; PET, positron emission tomography; rsfMRI, resting state functional magnetic resonance imaging.

Handels et al.

Handels et al. BMC Neurology 2012 12:72   doi:10.1186/1471-2377-12-72

Open Data