Open Access Research article

Intraocular pressure vs intracranial pressure in disease conditions: A prospective cohort study (Beijing iCOP study)

Zhen Li12, Yingxin Yang13, Yan Lu2, Dachuan Liu2, Erhe Xu4, Jianping Jia4, Diya Yang1, Xiaojun Zhang5, Huiqing Yang2, Daqing Ma6 and Ningli Wang1*

Author Affiliations

1 Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China

2 Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing, 100053, China

3 Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China

4 Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, 100053, China

5 Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China

6 Anaesthetics, Pain medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, London, SW10 9NH, UK

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BMC Neurology 2012, 12:66  doi:10.1186/1471-2377-12-66

Published: 3 August 2012

Abstract

Background

The correlation between intracranial pressure (ICP) and intraocular pressure (IOP) is still controversial in literature and hence whether IOP can be used as a non-invasive surrogate of ICP remains unknown. The aim of the current study was to further clarify the potential correlation between ICP and IOP.

Methods

The IOP measured with Goldmann applanation tonometer was carried out on 130 patients whose ICP was determined via lumber puncture. The Pearson correlation coefficient between ICP and IOP was calculated, the fisher line discriminated analysis to evaluate the effectivity of using IOP to predict the ICP level.

Results

A significant correlation between ICP and IOP was found. ICP was correlated significantly with IOP of the right eyes (p < 0.001) and IOP of the left eyes (p = 0.001) and mean IOP of both eyes (p < 0.001), respectively. However, using IOP as a measurement to predict ICP, the accuracy rate was found to be 65.4%.

Conclusion

Our data suggested that although a significant correlation exists between ICP and IOP, caution needs to be taken when using IOP readings by Goldmann applanation tonometer as a surrogate for direct cerebrospinal fluid pressure measurement of ICP.

Keywords:
Intracranial pressure; Intraocular pressure; Lumber puncture; Tonometer