Open Access Research article

Oxidative stress markers are associated to vascular recurrence in non-cardioembolic stroke patients non-treated with statins

David Brea1, Jaume Roquer2, Joaquín Serena3, Tomás Segura4, José Castillo1* and on behalf of the ARTICO STUDY

Author Affiliations

1 Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain

2 Department of Neurology, Hospital Universitari del Mar, Parc de Salut Mar, Barcelona, Spain

3 Department of Neurology, Hospital Universitario Dr. Josep Trueta, Institut d’Investigació Biomèdica de Girona, Girona, Spain

4 Servicio de Neurología, Hospital Universitario de Albacete, Albacete, Spain

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BMC Neurology 2012, 12:65  doi:10.1186/1471-2377-12-65

Published: 3 August 2012



Since atherogenesis is related to oxidative stress, our objective was to study the association of oxidative stress markers with the vascular recurrence in non-cardioembolic stroke.


Atherosclerotic and oxidative stress markers were evaluated on admission, in 477 patients suffering from a first non-cardioembolic stroke. Patients were followed at 6 and 12 months after inclusion, recording cardiovascular events. As markers of endothelial oxidative stress we used oxidized LDL, Cu/Zn superoxide dismutase and 8-OH deoxiguanosine. 136 patients were being treated with statins at the moment of serum samples acquisition.


Patients who suffered vascular recurrence or vascular-origin death had higher levels of 8-OHDG (40.06±24.70vs33.11±15.18;p=0.003). We also found associations between vascular recurrence or vascular origin death and Cu/ZnSOD (OR,1.02; 95%CI,1.00-1.03;p=0.0001) and 8-OHDG (OR,1.12;95%CI,1.08-1.16;p<0.0001) in a subgroup of 333 patients that were not in treatment with statins on admission. We also found associations between 8-OHDG and intima media thickness (IMT) (OR,1.13;95%CI,1.09-1.16;p<0.0001), presence of ipsilatieral stenosis≥50% (OR,1.03;95%CI1.00-1.05;p=0.007) and other atherosclerotic plaque characteristics.


Specific oxidative stress markers were found to be markers of atherosclerosis plaque types and vascular recurrence in non-statins treated patients at admission.

Ischemic stroke; Vascular recurrence; Atherothrombosis; Oxidative stress