Email updates

Keep up to date with the latest news and content from BMC Neurology and BioMed Central.

Open Access Research article

Oxidative stress markers are associated to vascular recurrence in non-cardioembolic stroke patients non-treated with statins

David Brea1, Jaume Roquer2, Joaquín Serena3, Tomás Segura4, José Castillo1* and on behalf of the ARTICO STUDY

Author Affiliations

1 Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain

2 Department of Neurology, Hospital Universitari del Mar, Parc de Salut Mar, Barcelona, Spain

3 Department of Neurology, Hospital Universitario Dr. Josep Trueta, Institut d’Investigació Biomèdica de Girona, Girona, Spain

4 Servicio de Neurología, Hospital Universitario de Albacete, Albacete, Spain

For all author emails, please log on.

BMC Neurology 2012, 12:65  doi:10.1186/1471-2377-12-65

Published: 3 August 2012



Since atherogenesis is related to oxidative stress, our objective was to study the association of oxidative stress markers with the vascular recurrence in non-cardioembolic stroke.


Atherosclerotic and oxidative stress markers were evaluated on admission, in 477 patients suffering from a first non-cardioembolic stroke. Patients were followed at 6 and 12 months after inclusion, recording cardiovascular events. As markers of endothelial oxidative stress we used oxidized LDL, Cu/Zn superoxide dismutase and 8-OH deoxiguanosine. 136 patients were being treated with statins at the moment of serum samples acquisition.


Patients who suffered vascular recurrence or vascular-origin death had higher levels of 8-OHDG (40.06±24.70vs33.11±15.18;p=0.003). We also found associations between vascular recurrence or vascular origin death and Cu/ZnSOD (OR,1.02; 95%CI,1.00-1.03;p=0.0001) and 8-OHDG (OR,1.12;95%CI,1.08-1.16;p<0.0001) in a subgroup of 333 patients that were not in treatment with statins on admission. We also found associations between 8-OHDG and intima media thickness (IMT) (OR,1.13;95%CI,1.09-1.16;p<0.0001), presence of ipsilatieral stenosis≥50% (OR,1.03;95%CI1.00-1.05;p=0.007) and other atherosclerotic plaque characteristics.


Specific oxidative stress markers were found to be markers of atherosclerosis plaque types and vascular recurrence in non-statins treated patients at admission.

Ischemic stroke; Vascular recurrence; Atherothrombosis; Oxidative stress