Table 3

Interaction betweenUCHL1 S18Y andSNCArs356220 polymorphisms affecting sporadic Parkinson’s disease in a Japanese population
SNCA rs356220
CC + CT TT
Genotype No. cases/controls Adjusted OR (95 % CI)* No. cases/controls Adjusted OR (95 % CI)*
CC + CA 92/182 1.00 67/97 1.44 (0.94 − 2.19)
AA 37/48 1.51 (0.91 − 2.53) 33/29 2.31 (1.29 − 4.14)
P for multiplicative interaction = 0.91
Measures of additive interaction
 Relative excess risk due to interaction (RERI) = 0.34 (95 % CI: -1.14 − 1.81)
 Attributable proportion due to interaction (AP) = 0.15 (95 % CI: -0.44 − 0.73)
 Synergy index (S) = 1.35 (95 % CI: 0.37 − 4.94)

*Adjusted for sex, age, region of residence, smoking, and caffeine intake.

Statistically significant when the 95 % CI of RERI > 0, the 95 % CI of AP > 0, or the 95 % CI of S > 1, indicating additive interaction.

Miyake et al.

Miyake et al. BMC Neurology 2012 12:62   doi:10.1186/1471-2377-12-62

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