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Open Access Research article

Swirl sign in intracerebral haemorrhage: definition, prevalence, reliability and prognostic value

Eufrozina Selariu1, Elisabet Zia2, Marco Brizzi2 and Kasim Abul-Kasim1*

Author Affiliations

1 Neuroradiology Division, Diagnostic Centre for Imaging and Functional Medicine, Lund University, Skåne University Hospital, Malmö, 205 02, Sweden

2 Department of Neurology, Lund University, Skåne University Hospital, Malmö, 205 02, Sweden

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BMC Neurology 2012, 12:109  doi:10.1186/1471-2377-12-109

Published: 26 September 2012

Abstract

Background

Swirl sign has previously been described in epidural hematomas as areas of low attenuation, radiolucency or irregular density. The aims of this study were to describe swirl sign in ICH, study its prevalence, study the reliability of the subjective evaluation on computed tomography (CT), and to explore its prognostic value.

Methods

CTs of 203 patients with ICH were retrospectively evaluated for the presence of swirl sign. Association between swirl sign and different clinical and radiological variables was studied.

Results

Inter- and intraobserver agreement with regard to the occurrence of swirl sign was substantial (К 0.80) and almost perfect (К 0.87), respectively. Swirl sign was found in 30% of the study population. 61% of patients with swirl sign were dead at one month compared with 21% of those with no swirl sign (p < 0.001). Only 19% of patients with swirl sign exhibited favorable outcome at three months compared with 53% of those with no swirl sign (p < 0.001). Patients with swirl sign exhibited larger ICHs with average ICH-volume 52 ± 50 ml (median 42 ml) compared with 15 ± 25 ml (median 6) in patients whose CT did not show swirl sign (p < 0.001). Swirl sign was independent predictor of death at one month (p = 0.03; adjusted odds ratio 2.6, 95% CI 1.1 – 6), and functional outcome at three months (p = 0.045; adjusted odds ratio 2.6, 95% CI 1.02 – 6.5).

Conclusions

As swirl sign showed to be an ominous sign, we recommend identification of this sign in cases of ICHs.

Keywords:
Swirl sign; Computed tomography; Reliability; Functional outcome; Haemorrhage volume