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Open Access Highly Accessed Debate

Neuroregeneration in neurodegenerative disorders

Ana M Enciu1, Mihnea I Nicolescu12, Catalin G Manole12, Dafin F Mureşanu3, Laurenţiu M Popescu12 and Bogdan O Popescu24*

Author Affiliations

1 Department of Cellular and Molecular Medicine, 'Carol Davila' University of Medicine and Pharmacy, School of Medicine, 8 Eroilor Sanitari, sector 5, Bucharest 050474, Romania

2 Laboratory of Molecular Medicine, 'Victor Babeş' National Institute of Pathology, 99-101 Splaiul Independenţei, sector 5, Bucharest 050096, Romania

3 Department of Neurology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 8, Victor Babeş, Cluj Napoca 400023, Romania

4 Department of Neurology, University Hospital Bucharest, 'Carol Davila' University of Medicine and Pharmacy, 169 Splaiul Independenţei, sector 5, Bucharest 050098, Romania

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BMC Neurology 2011, 11:75  doi:10.1186/1471-2377-11-75

Published: 23 June 2011

Abstract

Background

Neuroregeneration is a relatively recent concept that includes neurogenesis, neuroplasticity, and neurorestoration - implantation of viable cells as a therapeutical approach.

Discussion

Neurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's Disease or Parkinson's Disease and correlate with low endogenous protection, as a result of a diminished growth factors expression. However, we hypothesize that the brain possesses, at least in early and medium stages of disease, a "neuroregenerative reserve", that could be exploited by growth factors or stem cells-neurorestoration therapies.

Summary

In this paper we review the current data regarding all three aspects of neuroregeneration in Alzheimer's Disease and Parkinson's Disease.