Neuroregeneration in neurodegenerative disorders
1 Department of Cellular and Molecular Medicine, 'Carol Davila' University of Medicine and Pharmacy, School of Medicine, 8 Eroilor Sanitari, sector 5, Bucharest 050474, Romania
2 Laboratory of Molecular Medicine, 'Victor Babeş' National Institute of Pathology, 99-101 Splaiul Independenţei, sector 5, Bucharest 050096, Romania
3 Department of Neurology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 8, Victor Babeş, Cluj Napoca 400023, Romania
4 Department of Neurology, University Hospital Bucharest, 'Carol Davila' University of Medicine and Pharmacy, 169 Splaiul Independenţei, sector 5, Bucharest 050098, Romania
BMC Neurology 2011, 11:75 doi:10.1186/1471-2377-11-75Published: 23 June 2011
Neuroregeneration is a relatively recent concept that includes neurogenesis, neuroplasticity, and neurorestoration - implantation of viable cells as a therapeutical approach.
Neurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's Disease or Parkinson's Disease and correlate with low endogenous protection, as a result of a diminished growth factors expression. However, we hypothesize that the brain possesses, at least in early and medium stages of disease, a "neuroregenerative reserve", that could be exploited by growth factors or stem cells-neurorestoration therapies.
In this paper we review the current data regarding all three aspects of neuroregeneration in Alzheimer's Disease and Parkinson's Disease.