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Open Access Highly Accessed Research article

Identification of peripheral inflammatory markers between normal control and Alzheimer's disease

Sam-Moon Kim1, Juhee Song1, Seungwoo Kim1, Changsu Han2, Moon Ho Park3, Youngho Koh1, Sangmee Ahn Jo1 and Young-Youl Kim1*

Author Affiliations

1 Center for Biomedical Science, Division of Brain Diseases, National Institute of Health in Korea (KNIH), Osong Health Technology Administration Complex 643 Yeonje-ri, Gangoe-myeon, Chungcheongbuk-do, 363-951, Republic of Korea

2 Department of Psychiatry, Korea University Medical College, 516, Gojan-dong, Danwon-gu, Ansan-shi, Gyeonggi-do 425-707, Republic of Korea

3 Department of Neurology, Korea University Medical College, 516, Gojan-dong, Danwon-gu, Ansan-shi, Gyeonggi-do 425-707, Republic of Korea

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BMC Neurology 2011, 11:51  doi:10.1186/1471-2377-11-51

Published: 12 May 2011

Abstract

Background

Multiple pathogenic factors may contribute to the pathophysiology of Alzheimer's disease (AD). Peripheral blood markers have been used to assess biochemical changes associated with AD and mild cognitive impairment (MCI) and involved in their pathophysiology.

Methods

Plasma samples and clinical data were obtained from participants in the Ansan Geriatric Study (AGE study). Plasma concentrations of four candidate biomarkers were measured in the normal control (NC), MCI, and AD group: interleukin-8 (IL-8), IL-10, monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor-α (TNF-α).

Body mass index (BMI), MMSE (Mini Mental State Examination), CDR(Clinical Dementia Rating) score and homocystein level were recorded with social and demographic information.

Results

Total of 59 subjects were randomly selected for this analysis [NC (n = 21), MCI(n = 20) and AD(n = 18)]. In demographic data, educational year was correlated with the diagnosis states (p < 0.0001). No significant differences in cardiovascular disease, BMI and use of NSAIDs were found in MCI or AD group compared with NC group, respectively. The involvement of inflammatory illness or conditions in subjects, WBC count, fibrinogen and homocystein of the three groups, but no significant differences were found in each groups. The plasma IL-8 level was lower in MCI and AD patients compared with the normal control group (respectively, p < 0.0001). The MCI and AD patients had similar MCP-1, IL-10, and TNF-α level.

Conclusions

Our study suggests the existence of an independent and negative relationship between plasma IL-8 levels and functional status in MCI and AD patients.

Keywords:
IL-8; biomarker; Alzheimer's