Table 5

Drugs that may exacerbate RLS

Diphenhydramine (and other over the counter cold remedies)

Metoclopramide

Prochlorperazine

Chlordiazepoxide

Traditional antipsychotics (phenothiazines)

Atypical neuroleptics (olanzapine and risperidone)

Antidepressants (especially norepinehrine or selective serotonin reuptake inhibitors)

Anticonvulsants (zonisamide, phenytoin, methsuximide)

Antihistamines

Opiods

Garcia-Borreguero et al. BMC Neurology 2011 11:28   doi:10.1186/1471-2377-11-28