Table 4

Overview of treatments

Drug

Starting dose and maximum recommended dosage

Time to full effective therapeutic dose

Half-life

Side effects


Levodopa

50 mg

200 mg

At first dose

1.5-2 hours

Augmentation

Rebound


Ropinirole

0.25 mg

4 mg

4-10 days

6 hours

Nausea, low blood pressure, dizziness, headache, nasal congestion


Pramipexole

0.125 mg

0.54 mg

At first dose

8-12 hours

Nausea, low blood pressure, dizziness, headache, nasal congestion


Rotigotine

1-3 mg patches

1 week

5-7 hours

Skin irritation, nausea, low blood pressure, dizziness, headache, nasal congestion


Pregabalin

25-300 mg

3-6 days

10 hrs

Sleepiness, dizziness, headache, fluid retention


Clonazepam

0.50 mg

2.0 mg

First dose: effect mainly on sleep

30-40 hours

Sleepiness, dizziness, morning drug hangover


Gabapentin

300 mg

2700 mg

3-6 days

5-7 hours

Sleepiness, dizziness, fluid retention


Garcia-Borreguero et al. BMC Neurology 2011 11:28   doi:10.1186/1471-2377-11-28

Open Data