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## Figure 4.
Post-test probabilities for diagnosis of sCJD. Point estimates (closed circles for a positive test result; vertical bars for a
negative test result) and 95% credible intervals (horizontal bars) of post-test probabilities
for a diagnosis of sCJD are plotted for various CSF markers and cutoff thresholds.
For each estimate, Bayes' theorem was applied to CSF marker assay results, and 95%
credible intervals were estimated by modeling on a beta distribution using the software
Post_Test_Probabilities. Pre-test probability of sCJD (based on sCJD prevalence in
the overall study population) and 95% confidence interval are indicated by the open
circle and the horizontal bar. Cutoff thresholds used are listed on the left.
Coulthart |