CSF tau, S100B, and 14-3-3 joint distributions. Scatter plots of CSF concentrations of tau and S100B for (A) 118 sCJD cases and (B) 795 non-CJD cases. Dotted lines mark thresholds of 1,000, 3,000 and 5,000 pg/mL for tau, and 2.5 and 5.0 ng/mL for S100B. Filled and open circles indicate cases with positive and negative 14-3-3 results, respectively. To maintain S100B scales commensurate between plots, two non-CJD cases with S100B levels of 43.7 and 46.5 ng/mL and tau levels of 755.4 and 2,182 pg/mL, respectively, were excluded from plot B. Values of Spearman's ρ and respective significance levels are provided for each scatter plot.
Coulthart et al. BMC Neurology 2011 11:133 doi:10.1186/1471-2377-11-133