Table 4

Quantitative brain parenchyma venous vascular assessment in multiple sclerosis patients and healthy controls on pre- and post-contrast susceptibility-weighted images.

MS (n = 59)

Pre-contrast

Mean (SD)

MS (n = 48)

Post-contrast

Mean (SD)

HC (n = 33)

Pre-contrast

Mean (SD)

HC (n = 7)

Post-contrast

Mean (SD)

p-valuea

p-valueb

p-valuec

p-valued


ATVV for all vein diameters

66.9 (16.6)

68.9 (15.1)

82.9 (17.4)

91.6 (18.1)

< .0001

< .0001

NS

.01

ATVV with diameter < .3 mm

45 (10)

48.9 (7.9)

53.8 (10.2)

61.3(7.7)

< .0001

< .0001

NS

.01

ATVV with diameter .3-.6 mm

15.5 (4.4)

16.3 (4.6)

17.4 (4.7)

21.2 (5.2)

.068

.046

NS

.018

ATVV with diameter .6-.9 mm

4.5 (1.8)

4.5 (2)

4.9 (2)

5.3 (2)

NS

NS

NS

.044

ATVV with diamater > .9 mm

1.9 (0.9)

1.9 (1.2)

2.1 (0.9)

2.3 (0.9)

NS

NS

NS

NS


Venous intracranial fraction

0.061

(0.02)

0.062 (0.01)

0.067 (0.01)

0.069 (0.01)

.049

.05

NS

NS


Average distance from vein

1.24 (0.2)

1.23 (0.4)

1 (0.1)

0.94 (0.1)

< .0001

< .0001

NS

.018


RR (n = 41)

Pre-contrast

Mean (SD)

RR (n = 32)

Post-contrast

Mean (SD)

SP (n = 18)

Pre-contrast

Mean (SD)

SP (n = 9)

Post-contrast

Mean (SD)

p-valuee

p-valuef


ATVV for all vein diameters

64.5 (18.7)

66.5 (17.2)

72.4 (8.3)

74.2 (6.2)

.06

NS

ATVV with diameter < .3 mm

43.4 (11.1)

47.7 (8.5)

48.6 (7.1)

51.5 (5.9)

.046

NS

ATVV with diameter .3-.6 mm

14.9 (5)

15.4 (5.2)

16.9 (2.1)

18.3 (2)

NS

.048

ATVV with diameter .6-.9 mm

4.2 (2.1)

4.2 (2.2)

5.2 (0.6)

5.2 (0.4)

NS

NS

ATVV with diamater > .9 mm

1.8 (1.1)

1.7 (1.4)

2.3 (0.5)

2.1 (0.4)

NS

NS


Venous intracranial fraction

0.058

(0.02)

0.059

(0.01)

0.068 (0.008)

0.068

(0.008)

.025

.052


Average distance from vein

1.26 (0.2)

1.29 (0.4)

1.22 (0.2)

1.23 (0.2)

NS

NS


MS - Multiple Sclerosis; HC - Healthy Controls; RR - Relapsing-Remitting; SP - Secondary Progressive; NS - non significant; ATVV - apparent total venous volume

ATVV values are in milliliters and average distance from vein in millimeters.

p valuea - represents pre-contrast SWI VVV measure differences between MS patients and HC, p valueb - represents differences between MS patients post-contrast and HC pre-contrast SWI VVV measures, p valuec - represents pre- and post-contrast SWI VVV measure differences in MS patients, p valued - represents pre- and post-contrast SWI VVV measure differences in HC controls, p valuee represents pre-contrast SWI VVV measure differences between RR and SP patients, p valuef - represents post-contrast SWI VVV measure differences between RR and SP patients.

The differences between the study groups were tested using the Mann-Whitney rank sum test. The differences between pre-contrast and post-contrast SWI VVV measures in the same individuals were tested using the Wilcoxon signed rank test.

Zivadinov et al. BMC Neurology 2011 11:128   doi:10.1186/1471-2377-11-128

Open Data