Table 4 |
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|
Quantitative brain parenchyma venous vascular assessment in multiple sclerosis patients and healthy controls on pre- and post-contrast susceptibility-weighted images. |
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|
MS (n = 59) Pre-contrast Mean (SD) |
MS (n = 48) Post-contrast Mean (SD) |
HC (n = 33) Pre-contrast Mean (SD) |
HC (n = 7) Post-contrast Mean (SD) |
p-valuea |
p-valueb |
p-valuec |
p-valued |
|
|
|
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|
ATVV for all vein diameters |
66.9 (16.6) |
68.9 (15.1) |
82.9 (17.4) |
91.6 (18.1) |
< .0001 |
< .0001 |
NS |
.01 |
|
ATVV with diameter < .3 mm |
45 (10) |
48.9 (7.9) |
53.8 (10.2) |
61.3(7.7) |
< .0001 |
< .0001 |
NS |
.01 |
|
ATVV with diameter .3-.6 mm |
15.5 (4.4) |
16.3 (4.6) |
17.4 (4.7) |
21.2 (5.2) |
.068 |
.046 |
NS |
.018 |
|
ATVV with diameter .6-.9 mm |
4.5 (1.8) |
4.5 (2) |
4.9 (2) |
5.3 (2) |
NS |
NS |
NS |
.044 |
|
ATVV with diamater > .9 mm |
1.9 (0.9) |
1.9 (1.2) |
2.1 (0.9) |
2.3 (0.9) |
NS |
NS |
NS |
NS |
|
|
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|
Venous intracranial fraction |
0.061 (0.02) |
0.062 (0.01) |
0.067 (0.01) |
0.069 (0.01) |
.049 |
.05 |
NS |
NS |
|
|
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|
Average distance from vein |
1.24 (0.2) |
1.23 (0.4) |
1 (0.1) |
0.94 (0.1) |
< .0001 |
< .0001 |
NS |
.018 |
|
|
||||||||
|
RR (n = 41) Pre-contrast Mean (SD) |
RR (n = 32) Post-contrast Mean (SD) |
SP (n = 18) Pre-contrast Mean (SD) |
SP (n = 9) Post-contrast Mean (SD) |
p-valuee |
p-valuef |
|||
|
|
||||||||
|
ATVV for all vein diameters |
64.5 (18.7) |
66.5 (17.2) |
72.4 (8.3) |
74.2 (6.2) |
.06 |
NS |
||
|
ATVV with diameter < .3 mm |
43.4 (11.1) |
47.7 (8.5) |
48.6 (7.1) |
51.5 (5.9) |
.046 |
NS |
||
|
ATVV with diameter .3-.6 mm |
14.9 (5) |
15.4 (5.2) |
16.9 (2.1) |
18.3 (2) |
NS |
.048 |
||
|
ATVV with diameter .6-.9 mm |
4.2 (2.1) |
4.2 (2.2) |
5.2 (0.6) |
5.2 (0.4) |
NS |
NS |
||
|
ATVV with diamater > .9 mm |
1.8 (1.1) |
1.7 (1.4) |
2.3 (0.5) |
2.1 (0.4) |
NS |
NS |
||
|
|
||||||||
|
Venous intracranial fraction |
0.058 (0.02) |
0.059 (0.01) |
0.068 (0.008) |
0.068 (0.008) |
.025 |
.052 |
||
|
|
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|
Average distance from vein |
1.26 (0.2) |
1.29 (0.4) |
1.22 (0.2) |
1.23 (0.2) |
NS |
NS |
||
|
|
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|
MS - Multiple Sclerosis; HC - Healthy Controls; RR - Relapsing-Remitting; SP - Secondary Progressive; NS - non significant; ATVV - apparent total venous volume ATVV values are in milliliters and average distance from vein in millimeters. p valuea - represents pre-contrast SWI VVV measure differences between MS patients and HC, p valueb - represents differences between MS patients post-contrast and HC pre-contrast SWI VVV measures, p valuec - represents pre- and post-contrast SWI VVV measure differences in MS patients, p valued - represents pre- and post-contrast SWI VVV measure differences in HC controls, p valuee represents pre-contrast SWI VVV measure differences between RR and SP patients, p valuef - represents post-contrast SWI VVV measure differences between RR and SP patients. The differences between the study groups were tested using the Mann-Whitney rank sum test. The differences between pre-contrast and post-contrast SWI VVV measures in the same individuals were tested using the Wilcoxon signed rank test. |
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|
Zivadinov et al. BMC Neurology 2011 11:128 doi:10.1186/1471-2377-11-128 |
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