Table 1

Demographic and clinical characteristics in multiple sclerosis patients and healthy controls.

MS

(n = 59)

HC

(n = 33)

p

RR

(n = 41)

SP

(n = 18)

p


Female gender, n (%)

43 (72.9)

20 (60.6)

NS

28 (68.2)

15 (83.3)

NS


Age in years, mean (SD)

44.6 (11)

41.3 (11.1)

NS

40.5 (9.6)

53.8 (8.1)

< .0001


Age at onset, mean (SD)

30.9 (9.8)

----

---

30.6 (8.6)

31.7 (12.3)

NS


Disease duration, mean (SD)

13.3 (10)

---

---

9.5 (5.7)

21.9 (12)

< .0001


Expanded Disability Status Scale, mean (SD) median

3.2 (1) 2.5

---

---

2.1 (0.9) 2.0

5.9 (1.1) 6.0

< .0001


T2 lesion volume, mean (SD)

12.8 (15.2)

2.3 (2.5)

< .0001

8.9 (7.7)

21.9 (23)

.0014


T1 lesion volume, mean (SD)

2.5 (6.5)

---

---

1.3 (2.8)

5.5 (10.6)

.016


Gadolinium lesion volume, mean (SD)

0.07 (0.4)

---

---

0.1 (0.5)

0.01 (0.04)

NS


Normalized brain volume, mean (SD)

1545.1 (107.3)

1642.4 (81.8)

< .0001

1575.2 (94.5)

1476.4 (105.3)

.002


Normalized gray matter volume, mean (SD)

828

(97.2)

882.4 (112.8)

.022

855.8

(93.5)

764.7

74.5)

< .0001


Normalized white matter volume, mean (SD)

717.1

(68.5)

725.6

(72.6)

.018

719.5

(73)

711.7 (58.3)

NS


MS - Multiple Sclerosis; HC - Healthy Controls; RR - Relapsing-Remitting; SP - Secondary Progressive; EDSS - Expanded Disability Status Scale; NS - non significant

All volumes are expressed in milliliters.

The differences between the study groups were tested using the chi-square, Student's t-test and the Mann-Whitney rank sum test.

Zivadinov et al. BMC Neurology 2011 11:128   doi:10.1186/1471-2377-11-128

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