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Open Access Research article

Gender-dependence of substituted judgment on quality of life in patients with dementia

Claudia Schiffczyk1, Christina Jonas1, Constanze Lahmeyer1, Friedemann Müller2 and Matthias W Riepe1*

Author Affiliations

1 Department of Psychiatry and Psychotherapy II, Mental Health & Old Age Psychiatry, Ulm University, Ulm, Germany

2 Alzheimer Therapiezentrum Bad Aibling, Bad Aibling, Germany

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BMC Neurology 2011, 11:118  doi:10.1186/1471-2377-11-118

Published: 30 September 2011

Abstract

Background

Substituted judgment asks the proxy to decide what the patient would have decided, had he or she been competent. It is unclear whether substituted judgment of the patient's quality of life can serve as a surrogate measure in patients with dementia.

Methods

212 patients with dementia and their proxies were interviewed in their homes. Dementia syndrome was characterized with cognitive, non-cognitive and functional scales. Quality of life (QoL) was assessed with the QoL-AD.

Results

Substituted judgment of the patient's QoL was unrelated to dementia severity but also correlated with the proxie's own QoL (r = 0.356; p < 0.001). Gender-specific analysis reveals that for male proxies the most important variable is severity of patient's depression (r = -0.895; p = 0.001) while for female proxies it is the proxie's own QoL (r = 0.371; p < 0.001). Subjective burden correlates with the proxie's QoL in females (r = -0.282; p = 0.001) but not in males (r = -0.163, p = 0.161).

Conclusion

Substituted judgment of the patient's QoL does not correlate with dementia severity. Substituted judgment is subject to proxy-related variables in a gender-dependent fashion and therefore not suited to serve as an appropriate surrogate of the patients' quality of life.