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Open Access Research article

Dynamic cerebral autoregulation after intracerebral hemorrhage: A case-control study

Kazuma Nakagawa12*, Jorge M Serrador34, Sarah L LaRose4 and Farzaneh A Sorond4

Author Affiliations

1 Neuroscience Institute, The Queen's Medical Center, Honolulu, Hawaii, USA

2 Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA

3 War Related Injury and Illness Study Center, New Jersey Veterans Administration & Veterans Biomedical Research Institute, East Orange, New Jersey, USA

4 Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

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BMC Neurology 2011, 11:108  doi:10.1186/1471-2377-11-108

Published: 31 August 2011

Abstract

Background

Dynamic cerebral autoregulation after intracerebral hemorrhage (ICH) remains poorly understood. We performed a case-control study to compare dynamic autoregulation between ICH patients and healthy controls.

Methods

Twenty-one patients (66 ± 15 years) with early (< 72 hours) lobar or basal ganglia ICH were prospectively studied and compared to twenty-three age-matched controls (65 ± 9 years). Continuous measures of mean flow velocity (MFV) in the middle cerebral artery and mean arterial blood pressure (MAP) were obtained over 5 min. Cerebrovascular resistance index (CVRi) was calculated as the ratio of MAP to MFV. Dynamic cerebral autoregulation was assessed using transfer function analysis of spontaneous MAP and MFV oscillations in the low (0.03-0.15 Hz) and high (0.15-0.5 Hz) frequency ranges.

Results

The ICH group demonstrated higher CVRi compared to controls (ipsilateral: 1.91 ± 1.01 mmHg·s·cm-1, p = 0.04; contralateral: 2.01 ± 1.24 mmHg·s·cm-1, p = 0.04; vs. control: 1.42 ± 0.45 mmHg·s·cm-1). The ICH group had higher gains than controls in the low (ipsilateral: 1.33 ± 0.58%/mmHg, p = 0.0005; contralateral: 1.47 ± 0.98%/mmHg, p = 0.004; vs. control: 0.82 ± 0.30%/mmHg) and high (ipsilateral: 2.11 ± 1.31%/mmHg, p < 0.0001; contralateral: 2.14 ± 1.49%/mmHg, p < 0.0001; vs. control: 0.66 ± 0.26%/mmHg) frequency ranges. The ICH group also had higher coherence in the contralateral hemisphere than the control (ICH contralateral: 0.53 ± 0.38, p = 0.02; vs. control: 0.38 ± 0.15) in the high frequency range.

Conclusions

Patients with ICH had higher gains in a wide range of frequency ranges compared to controls. These findings suggest that dynamic cerebral autoregulation may be less effective in the early days after ICH. Further study is needed to determine the relationship between hematoma size and severity of autoregulation impairment.

Keywords:
Cerebral autoregulation; Intracerebral hemorrhage; TCD Ultrasound