Email updates

Keep up to date with the latest news and content from BMC Neurology and BioMed Central.

Open Access Research article

Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study

Mi-Ryung Han14, Gerard D Schellenberg23, Li-San Wang234* and the Alzheimer's Disease Neuroimaging Initiative

Author Affiliations

1 Genomics and Computational Biology Program, University of Pennsylvania, Philadelphia, PA 19104, USA

2 Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

3 Institute on Aging, University of Pennsylvania, Philadelphia, PA 19104, USA

4 Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA

For all author emails, please log on.

BMC Neurology 2010, 10:90  doi:10.1186/1471-2377-10-90

Published: 8 October 2010

Additional files

Additional file 1:

Demographic, clinical and biomarker data for each subject group before removing 20 outliers (n = 410: Normal, MCI and AD).

Format: DOC Size: 42KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 2:

Ethnic and Racial summary for ADNI data.

Format: DOC Size: 32KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 3:

Population stratification assessments using PCA. Colors indicate different ethnic (A) and racial (B) groups. The x-axis indicates the first principal component (PC0) and y-axis indicates the second principal component (PC1).

Format: DOC Size: 119KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 4:

Log10(CSF levels) for each subject group after removing 20 outliers (n = 390: Normal, MCI and AD).

Format: DOC Size: 35KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 5:

Log10(CSF levels) for each subject group before removing 20 outliers (n = 410: Normal, MCI and AD).

Format: DOC Size: 35KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 6:

Quantile-Quantile plots of three CSF biomarkers in case/control (left: GENO_2DF test, middle: DOMDEV test, right: ADD test). The x-axis indicates quantile values (-log10(quantile values)) and y-axis indicates p-values (-log10(observed p-values)).

Format: DOC Size: 154KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 7:

Enriched GO Categories (Top 10 GO categories with p-value < 10-2).

Format: DOC Size: 148KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 8:

Significant SNPs (p-value < 10-4) known to be associated with gene expression in published eQTL studies.

Format: DOC Size: 226KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data