Table 4

Adjusted means and mean difference between pregabalin and placebo, and gabapentin and placebo, for seizure-free days over the last 28 days

Dose

Mean Change in SFD

S.E.

Mean Difference Between Active and Placebo

95% CI for Mean Difference


Pregabalin


150 mg

5.40

0.35

2.29

1.87, 2.72

300 mg

5.71

0.36

2.61

2.12, 3.10

450 mga

5.90

0.36

2.80

2.28, 3.32

600 mg

6.03

0.36

2.93

2.38, 3.47

Placebo

3.10

0.39

-

-


Gabapentin


900 mg

4.42

0.36

1.32

0.82, 1.82

1200 mg

4.48

0.37

1.37

0.85, 1.89

1800 mg

4.56

0.37

1.45

0.90, 2.00

2400 mga

4.61

0.38

1.51

0.94, 2.08

Placebo

3.10

0.38

-

-


aNote that 450 mg pregabalin and 2400 mg gabapentin were not studied in any of the trials; these results were calculated from the dose-response equation.

CI = confidence interval; S.E. = standard error; SFD = seizure-free days over the last 28 days

Delahoy et al. BMC Neurology 2010 10:104   doi:10.1186/1471-2377-10-104

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