Table 3

Adjusted mean biomarker levels at the baseline visit of the MESA study, in participants with and without chronic kidney disease

Biomarker (units)

CKD Mean levels (95% CI)

No CKD Mean levels (95% CI)

P-value


CRP (log mg/L) N = 6750

0.81 (0.73, 0.89)

0.63 (0.61, 0.66)

<0.001

IL-6 (log pg/mL) N = 6622

0.37 (0.33, 0.41)

0.19 (0.18, 0.21)

<0.001

TNF-αR1 (pg/mL) N = 995

1.90 (1.76, 2.03)

1.23 (1.22, 1.25)

<0.001

ICAM-1 (ng/mL) N = 2611

281 (271, 290)

274 (271, 277)

0.19

Fibrinogen (mg/dL) N = 6750

363 (360, 372)

345 (343, 346)

<0.001

Factor VIII (%) N = 6750

187 (181, 193)

161 (160, 163)

<0.001


All biomarker models adjusted for age, gender, race/ethnicity, smoking status, BMI, diabetes, hypertension, LDL, HDL, and use of statins

Chronic kidney disease (CKD) defined as eGFR < 60 mL/min/1.73 m2

Keller et al. BMC Nephrology 2008 9:9   doi:10.1186/1471-2369-9-9

Open Data