Table 1

Baseline characteristics of MESA population by quintiles of cystatin C

Cystatin C (mg/L)


Quintile 1

Quintile 2

Quintile 3

Quintile 4

Quintile 5

≤ 0.74

0.75–0.82

0.83–0.89

0.91–1.02

≥ 1.03

(n = 1446)

(n = 1377)

(n = 1283)

(n = 1359)

(n = 1285)


Mean ± SD, Median [IQR], or %

p-value for trend


Age

57 ± 9

59 ± 9

62 ± 9

65 ± 10

69 ± 10

<0.001

Female, %

65

53

49

47

49

<0.001

Race/Ethnicity, %

White

33

34

41

41

44

Chinese

17

13

10

11

8

African-American

30

30

26

24

28

Hispanic

19

24

23

24

20

Smoking History, %

44

49

50

53

53

<0.001

BMI (kg/m2)

27 ± 5

28 ± 5

28 ± 5

29 ± 6

30 ± 6

<0.001

Diabetes, %

14

13

12

12

21

<0.001

Hypertension, %

34

36

43

50

64

<0.001

LDL (mg/dL)

117 ± 32

119 ± 31

118 ± 31

117 ± 32

114 ± 32

0.006

HDL (mg/dL)

56 ± 16

51 ± 15

51 ± 14

49 ± 14

48 ± 14

<0.001

Glucose (mg/dL)

105 ± 37

104 ± 32

102 ± 22

104 ± 28

107 ± 31

0.128

Medication use, %

ACE-inhibitors

0.6

0.9

0.9

1.5

1.9

0.005

Beta-blockers

0.3

0.4

0.9

0.7

0.5

0.427

Statin use

11

14

15

16

19

<0.001

Urinary albumin/creatinine ratio (mg/g)

5.1 [3.4, 10.3]

5.1 [3.2, 9.5]

5.1 [3.1, 9.0]

5.3 [3.3, 10.7]

7.4 [3.9, 20.0]

<0.001

Serum cystatin C (mg/L)

0.68 ± 0.06

0.77 ± 0.02

0.86 ± 0.02

0.96 ± 0.03

1.22 ± 0.36

<0.001

Creatinine-based eGFR (ml/min/1.73 m2)

93 ± 16

87 ± 15

82 ± 19

77 ± 13

65 ± 16

<0.001


To convert LDL or HDL from mg/dL to mmol/L, divide by 39; to convert glucose, divide by 18; to convert urinary albumin/creatinine ratio from mg/g to mg/mmol, multiply by 0.114; to convert serum creatinine from mg/dL to μmol/L, multiply by 88.

Keller et al. BMC Nephrology 2008 9:9   doi:10.1186/1471-2369-9-9

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