Figure 1.

p21 is decreased in kidneys from ADPKD patients. [top] Kidney protein extracts from control (closed) and PKD (open) human males were immunoblotted with an anti-p21 and β-actin antibody. Immunoblots were analyzed by densitometry with ImageJ as described in Methods. [bottom] p21 expression is presented as the ratio of intensity of p21 bands compared to intensity of actin bands presented as mean ± SEM. * p < 0.01 versus within gender control. Values within each bar denote the number of kidneys utilized.