Table 7

Clinical and histologic differences between ANCA (+) and ANCA (-) patients

ANCA (+) N = 26

ANCA (-) N = 8

p


I. Clinical


Age (years)

60 ± 13

42 ± 20

0,005

pCreatinine at biopsy (mg/dl)

6.11 ± 4.7

5.7 ± 1.8

NS

pUrea at biopsy (mg/dl)

128.3 ± 69.3

109.4 ± 25.5

NS

CRP (mg/l)

64.7 ± 75

99 ± 86

NS

ESR (mm/1 h)

116 ± 28

108 ± 44

NS

24 h urinary albumin excretion (g)

2.21 ± 1.12

1.17 ± 0.77

0,005


II. Histologic


Crescents (%)

63 ± 33

52 ± 32

NS

Cellular crescents

59 ± 44

51 ± 47

NS

Fibrocellular crescents

11 ± 26

51 ± 47

NS(0.06)

Fibrous crescents

12 ± 24

11 ± 21

NS

Obsolete glomeruli

25 ± 23

35 ± 19

NS

Focal necrosis

1.34 ± 0.48

1.62 ± 0.52

NS

TIN infiltration

1.36 ± 1.13

1.87 ± 0.99

NS

Tubular atrophy

1.13 ± 0.97

1.5 ± 0.93

NS

TIN fibrosis

1.4 ± 1.1

1.59 ± 0.5

NS

Arterial sclerosis

1.79 ± 1.06

2.25 ± 0.96

0.05


Abbrev: CRP, C-reactive protein, ESR, erythrocyte sedimentation rate, TIN, tubulointerstitial

Alexopoulos et al. BMC Nephrology 2006 7:16   doi:10.1186/1471-2369-7-16

Open Data