Table 10

Differences in immunohistochemical findings between MPO-ANCA (+) and PR3-ANCA (+) patients

MPO-ANCA (+) N = 17

PR3-ANCA (+) N = 9

p


I. Glomeruli


PCNA(+) cells

28 ± 14

47 ± 12

NS

α-SMA(+)cells

36 ± 12

32 ± 23

NS

Monocytes/macrophages

17 ± 12

12 ± 3

NS

LFA-1β(+)cells

14 ± 5

21 ± 8

NS

TGF-β1 expression

1.0 ± 0.7

1.5 ± 0.7

NS

ICAM-1 expression

1.5 ± 0.67

1.66 ± 0.58

NS

C5b-9 expression

2.2 ± 1.08

2.5 ± 0.58

NS


II. Tubulointerstitium


HLA-DR(+) cells

1293 ± 894

866 ± 467

NS

PCNA(+)cells

757 ± 166

947 ± 92

0.041

α-SMA(+)cells

702 ± 222

779 ± 348

NS

Monocytes/macrophages

550 ± 181

614 ± 264

NS

LFA-1β(+)cells

469 ± 157

552 ± 106

NS

ICAM-1 in tubules

35.4 ± 10.8

29.4 ± 15

NS

C5b-9 in tubules

30.6 ± 9,4

37.3 ± 10.2

NS

TGF-β1 in interstitium

1.45 ± 0.7

2.67 ± 0.6

0.017

TGF-β1 in tubules

1.67 ± 0.78

2.25 ± 0.96

NS

ICAM-1in vessels

1,18 ± 0,4

1.3 ± 0.57

NS

C5b-9 in vessels

1.08 ± 0.29

1.0 ± 0.07

NS


Alexopoulos et al. BMC Nephrology 2006 7:16   doi:10.1186/1471-2369-7-16

Open Data