Table 6 |
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Effect of experimental hypothyroidism on antioxidant enzymes activities. |
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|
Ref. |
Specie |
MHI |
Change in antioxidant enzymes |
|
|
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|
61 |
Rat |
MMI |
↑ MnSOD and CAT and ↔ Cu, ZnSOD in brown adipose tissue. |
|
62 |
Rat |
PTU |
In liver mitochondria: ↑ Total and Cu, ZnSOD, ↔ MnSOD, ↓ CAT. ↑ Total and Se-independent and Se-dependent GPx |
|
63 |
Rat |
PTU |
↓ SOD and ↔ CAT in heart. |
|
64 |
Rat |
MMI |
↑ GPx, ↔ CAT, and total SOD in heart. |
|
65 |
Rat |
PTU |
↓ SOD and CAT and ↑ GPx in testis. |
|
66 |
Rat |
PTU |
In brain: ↑ Total and MnSOD, CAT, total and Se-dependent GPx. ↓ Se-independent GPx, and GR. |
|
55 |
Rat |
MMI |
In cerebral cortex: ↑ Total SOD, Cu, ZnSOD, and GPx, and ↓ MnSOD. ↔ CAT. |
|
67 |
Rat |
Na131I |
↓ SOD, ↔ CAT, and ↑ GPx in kidney. ↓ Plasma GPx. |
|
47 |
Rat |
PTU |
Cu, ZnSOD ↔ in extensor digitorum longus and soleus muscles, ↑ heart, and ↓ liver. GPx ↔ in soleus muscle and liver ↑ extensor digitorum longus muscle and heart. |
|
68 |
Rat |
MMI |
GPx ↑ in gastrocnemius muscle and heart, and ↔ in liver. GR in ↔ heart, gastrocnemius muscle, and liver. |
|
|
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|
Ref. = reference, MHI = Method of hypothyroidism induction, PTU = 6-n-propyl-2-thiouracil, MMI = methimazole, ↑ = increase, ↓ = decrease, ↔ = without change, SOD = superoxide dismutase, MnSOD = manganese-dependent superoxide dismutase, Cu, ZnSOD = copper,zinc-dependent superoxide dismutase, Se = selenium, GPx = Glutathione peroxidase, GR = glutathione reductase, CAT = catalase. |
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Tenorio-Velázquez et al. BMC Nephrology 2005 6:12 doi:10.1186/1471-2369-6-12 |
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