Table 1

PTH (pg/mL) and Ca (mg/dL) levels in 5/6 Nx repeat-dose study
PTH
Week Hour post dosing Cinacalcet AMG 416 Vehicle
Week 1 6 hr 128 ± 44 30 ± 6 758 ± 191
16 hr 312 ± 72 155 ± 30 472 ± 126
Week 4 6 hr 115 ± 73 18 ± 4 451 ± 162
16 hr 700 ± 315 66 ± 18 357 ± 69
Calcium
Week Hour post dosing Cinacalcet AMG 416 Vehicle
Week 1 6 hr 8.9 ± 0.3 8.0 ± 0.3 10.4 ± 0.3
16 hr 10.0 ± 0.3 8.5 ± 0.3 11.0 ± 0.3
Week 4 6 hr 9.3 ± 0.4 8.9 ± 0.3 10.7 ± 0.2
16 hr 10.3 ± 0.5 9.2 ± 0.4 11.1 ± 0.2

Data shown are group means ± SEM.

Walter et al.

Walter et al. BMC Nephrology 2014 15:81   doi:10.1186/1471-2369-15-81

Open Data