AMG 416 administration lowers PTH in a severe model of kidney dysfunction. Rats subjected to IKIC surgery were treated with a single dose of either: AMG 416 by IV bolus injection (0.5 mg/kg), cinacalcet by po administration (30 mg/kg), or saline IV bolus (0.5 mL). Serum creatinine levels (mg/dL) for the three groups were: AMG 416 (5.5), cinacalcet (5.1), saline (6.1). Blood samples were removed at indicated times to measure plasma PTH. Mean group baseline PTH levels (pg/mL) prior to dosing were: AMG 416 (667), cinacalcet (949), saline (1026). Data are presented as group mean ± SEM (AMG 416, n = 5; cinacalcet n = 6; saline, n = 3). *, p < 0.05 vs. saline.
Walter et al. BMC Nephrology 2014 15:81 doi:10.1186/1471-2369-15-81