Factors associated with chronic musculoskeletal pain in patients with chronic kidney disease
1 Department of Nephrology, Chang Gung Memorial Hospital, 222, Mai-Chin Road, Keelung 20401, Taiwan
2 The Graduate Institute of Clinical Medical Sciences, Chang Gung University Medical College, Taoyuan School of Medicine, Taipei, Taiwan
3 Chang Gung University, Taipei, Taiwan
4 Department of Pediatrics and Rheumatology, Taipei Medical University Hospital, Taipei, Taiwan
5 Laboratory of Epidemiology, Department of Health Care Management, Chang Gung University, Taipei, Taiwan
6 Department of Cardiology, Chang Gung Memorial Hospital, Keelung, Taiwan
7 Division of Nephrology, Taipei Medical University Hospital, Taipei, Taiwan
8 Department of Internal Medicine, Taipei Medical University, Taipei, Taiwan
BMC Nephrology 2014, 15:6 doi:10.1186/1471-2369-15-6Published: 8 January 2014
Chronic musculoskeletal (MS) pain is common in patients with chronic kidney disease (CKD) undergoing haemodialysis. However, epidemiological data for chronic MS pain and factors associated with chronic MS pain in patients with early- or late-stage CKD who are not undergoing dialysis are limited.
A cross-sectional study to evaluate the prevalence of chronic MS pain and factors associated with chronic MS pain in patients with early- and late-stage CKD who were not undergoing dialysis, was conducted. In addition, the distribution of pain severity among patients with different stages of CKD was evaluated.
Of the 456 CKD patients studied, 53.3% (n = 243/456) had chronic MS pain. Chronic MS pain was independently and significantly associated with hyperuricemia as co-morbidity, as well as with the calcium × phosphate product levels. In CKD patients with hyperuricemia, chronic MS pain showed a negative, independent significant association with diabetes mellitus as a co-morbidity (odds ratio: 0.413, p = 0.020). However, in the CKD patients without hyperuricemia as a co-morbidity, chronic MS pain showed an independent significant association with the calcium × phosphate product levels (odds ratio: 1.093, p = 0.027). Furthermore, stage-5 CKD patients seemed to experience more severe chronic MS pain than patients with other stages of CKD.
Chronic MS pain is common in CKD patients. Chronic MS pain was independently and significantly associated with hyperuricemia as co-morbidity, and with the calcium × phosphate product levels in early- and late-stage CKD patients who were not on dialysis.