Table 2

The profile of sub-cohort with a creatinine clearance (Ccr) of more than 90 mL/min/1.73 m2
Total Lean sub-group Overweight sub-Group Obese sub-Group P value
N. of patients 129 46 51 32
Age (years) 52.6 ± 9.05 53.1 ± 9.36 52.1 ± 9.04 52.5 ± 8.82 0.883
Male sex (%) 78 (60.5%) 28 (60.9%) 31 (60.8%) 19 (59.3%) 0.987
BMI (kg/m2) 25.9 ± 3.05 23.0 ± 1.36 26.4 ± 0.84 30.5 ± 1.73 -
Ccr (mL/min/1.73 m2) 148 ± 38 138 ± 31 151 ± 40 159 ± 42** 0.027
  >150 mL/min/1.73 m2 (%) 93 (72.1%) 28 (60.9%) 37 (72.5%) 28 (87.5%)* 0.036
Known duration of diabetes (months) 83.6 ± 68.8 91.7 ± 57.4 80.8 ± 63.8 76.6 ± 59.6 0.746
Known duration of proteinuria (months) 22.0 ± 25.6 20.0 ± 25.3 24.7 ± 26.1 20.5 ± 26.7 0.549
Fasting glucose (mg/dL) 131 ± 48 134 ± 52 122 ± 35 143 ± 60 0.184
HbA1c (%) 6.81 ± 1.46 7.04 ± 1.71 6.48 ± 1.21 7.03 ± 1.35 0.133
Mean blood pressure (mm Hg) 105 ± 13.4 106 ± 15.3 103 ± 11.7 105 ± 12.9 0.364
Proteinuria (g/24 h) 2.36 ± 2.33 2.39 ± 2.39 2.29 ± 2.32 2.43 ± 2.33 0.901
  ≥3.5 g/24 h (%) 30 (23.2%) 9 (19.6%) 13 (25.5%) 8 (25.0%) 0.760
Serum albumin (g/dL) 3.66 ± 0.77 3.47 ± 0.74 3.69 ± 0.77 3.78 ± 0.81 0.224
Serum creatinine (mg/dL) 0.88 ± 0.25 0.89 ± 0.21 0.89 ± 0.27 0.86 ± 0.24 0.987
Hemoglobin (g/dL) 12.7 ± 2.2 12.0 ± 2.0 12.8 ± 2.2 13.6 ± 2.2 0.016
  Anemia (%) 33 (25.6%) 19 (41.3%) 10 (19.6%) 4 (12.5%) 0.007
  High hemoglobin (%) 17 (13.2%) 5 (10.9%) 6 (11.8%) 6 (18.8%) 0.338
Volume of glomerulus (×106 μm3) 5.45 ± 0.0.55 4.79 ± 0.31 5.44 ± 0.57* 6.40 ± 0.71** 0.014
Meanglobal sclerosis (%) 16.3 ± 16.4 13.3 ± 13.6 15.7 ± 17.0 21.7 ± 19.6 0.178
Mesangial expansion (0–3) 1.70 ± 0.80 1.96 ± 0.84 1.54 ± 0.78 1.62 ± 0.59 0.698
K-W nodule (%) 55 (42.6%) 27 (58.7%) 18 (35.3%)* 10 (31.3%)* 0.012
Interstitial fibrosis (0–3) 1.20 ± 0.66 1.62 ± 0.64 1.50 ± 0.59 1.23 ± 0.31 0.430
Tubular atrophy (0–3) 0.98 ± 0.30 1.05 ± 0.32 0.95 ±0.30 0.94 ± 0.24 0.267

NOTE. Values were expressed as mean ± SD or number (percentage); Abbreviation: BMI, body mass index; K-W, Kimmelstiel-Wilson; Ccr, creatinine clearance rate. To convert serum creatinine in mol/L to mg/dL, multiply by 0.0113; creatinine clearance rate in mL/s/1.73 m2 to mL/min/1.73 m2, multiply by 60.0. The listed P values are based on ANOVA or Chi-square test. *P < 0.05 and **P < 0.01 versus lean group.

Chen et al.

Chen et al. BMC Nephrology 2013 14:69   doi:10.1186/1471-2369-14-69

Open Data