Table 3

Predictors of ESA resistance
Predictors
Model 1 Model 2 Model 3
Clinical parameters Model 1 plus routine laboratory Model 2 plus specific biomarkers
OR 95% CI p-value OR 95% CI p-value OR 95% CI p-value
Sex (male) 1,72 1.27-2.32 <0.001 1,73 1.22-2.45 0.002 1,54 1.08-2.21 0.017
BMI (kg/m2) 0.97 0.94-1.00 0.048 0.96 0.93-0.996 0.03 0,96 0.92-0.99 0.02
dialysis vintage (mo) 0.97 0.95-0.99 0.011
CHF (%) 1,41 1.04-1.91 0.028 1,34 0.96-1.87 0.08 1,30 0.92-1.84 0.14
ACE-inhibitors (%) 1,32 0.98-1.78 0.071 1,33 0,96-1,84 0.09
heart rate (bpm) 1,01 1,00-1,02 0.052 1,01 1.00-1.02 0.029
albumin (g/dl) 0,29 0.17-0.52 <0.001 0,40 0.22-0.72 0.002
LDL-cholesterol (mg/dl) 0.996 0.99-1.001 0.125 0.995 0.989-1.001 0.098
creatinine (mg/dl) 1,08 0.99-1.17 0.087
urea (mg/dl) 0.996 0.991-1.001 0.10
iron saturation (%) 0,94 0.93-0.96 <0.001 0.95 0.93-0.97 <0.001
potassium (mmol/l) 1,21 0.99-1.47 0.062 1,34 1.09-1.64 0.005
CRP (mg/l) 1,18 1.02-1.38 0.028
Troponin T (ng/ml) 1,17 0.97-1.42 0.10
ADMA (umol/l) 5,24 1.75-15.70 0.003
Osteocalcin (ug/l) 0,82 0.66-1.01 0.064

Schneider et al.

Schneider et al. BMC Nephrology 2013 14:67   doi:10.1186/1471-2369-14-67

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