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Open Access Research article

Intrarenal resistance index for the assessment of acute renal injury in a rat liver transplantation model

Hai-Ying Kong1, Fen Chen2, Yong He2, Lin-Jiao Wu3, Li-Qing Wang1, Sheng-Mei Zhu1 and Shu-Sen Zheng2*

Author Affiliations

1 Department of Anesthesiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, PR China

2 Key Lab of combined Multi-organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, PR China

3 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases; Key Laboratory of Infectious Diseases, Zhejiang Province; Department of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, PR China

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BMC Nephrology 2013, 14:55  doi:10.1186/1471-2369-14-55

Published: 2 March 2013

Abstract

Background

Acute kidney injury (AKI) is a common complication after liver transplantation (LT) and associated with a high mortality. The renal resistive index (RI) is used to assess early renal function impairment in critical care patients. However, limited data are available concerning changes of renal RI and the development of AKI early after reperfusion. We approached to investigate the changes of renal RI and AKI after reperfusion in a rat liver transplantation model.

Methods

Rats were randomly divided into sham group or LT group. Ten rats in each group were used for the hemodynamic study and twenty for Doppler measurements during the procedure. Ten rats were sacrificed 30 min or 2 h after the reperfusion. We harvested kidneys, serum and urine for further analysis of the renal function.

Results

The intrarenal RI increased significantly in the anhepatic stage and decreased significantly after the reperfusion in the LT group compared with sham group (P < 0.05). AKI was seen after the reperfusion in the LT group. No correlation was noted between the RI and renal function parameters 30 min after reperfusion.

Conclusions

The intrarenal RI increased significantly during the anhepatic stage, and decreased significantly early after the reperfusion. Intrarenal RI was unable to assess renal function in a rat liver transplantation model.

Keywords:
Liver transplantation; Doppler sonography; Renal function; Resistive index; Cys; NGAL