Table 2

Data from the multicentric French cohort
All patients Patients with normal platelets count Patients with thrombocytopenia P
Number of patients 107 14 93
Number of episodes 145 17 128
Number of relapsing patients 18 (20%) 2 (14%) 19 (20%) 0.88
Sex (%male) 29 (27%) 5 (36%) 24 (26%) 0.39
Age (years) 32 [22 – 45] 32 [22 – 45] 33 [23 – 42] 0.78
Biopsy proven TMA 72 (67%) 13 (93%) 59 (63%)
identification of mutation 75 (70%) 10 (71%) 65 (70%) 0.95
  CFH 40 6 34
  CFI 17 3 14
  MCP 10 1 9
  C3 11 1 10
  CFB 2
  Anti-factor H Autoantibody 2
Potential explanation 2 (13.3%) 1 (14.3%) 11 (12%)
  Familial form 1 10
  Low C3 2 0 1
Idiopathic 21 (23.3%) 3 (21.4%) 19 (25%)
Pregnancy associated HUS 19 (18%) 1 (7%) 17 (18%) 0.151
Platelets (G/L)* 79 [48-117] 214 [186 - 242] 68 [46-100] < 0.001
Hb (g/dl) 7.2 [6,6 - 9] 8.6 [6.7-10] 7.2 [6.6 - 8.8] 0.16
LDH* (UI/L) 1688 [951-2930] 664 [498-1914] 1711 [999-1953] 0.017
Creatinine (mg/dl) 7.3 [4.1 - 11.3] 4.3 [2.6 - 12] 7.6 [4.6 - 11.3] 0.27
HD at the diagnosis 13 (12%) 1 (7%) 12 (13%) 0.68
HD during the episode 72 (80%) 10 (71%) 62 (81.6%) 0.6
Death Number/% 6 (6.7%) 1 (7.1%) 5 (6.6%) 0.9

For Numeric value, data are express in Median value [25%-75%], for categories, data are express in number of observation (%). Test used, Mann Whitney test (quantitative data) and Fisher's test for proportion and rate. Note, Conversion factors for units, serum creatinine in mg/dL to mol/L, ×88.4; serum urea nitrogen in mg/dL to mmol/L.

Sallée et al.

Sallée et al. BMC Nephrology 2013 14:3   doi:10.1186/1471-2369-14-3

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