Table 4

Clinical characteristics of the CKD patients according to quartiles of FGF23 levels
FGF23-Quartile 1 FGF23-Quartile 2 FGF23-Quartile 3 FGF23-Quartile 4
(n = 47; FGF23, 11–40) (n = 50; FGF23, 41–63) (n = 49; FGF23, 64–103) (n = 49; FG23, 105–2010) p values
Age (years) 67.7 ± 14.2 68.5 ± 10.6 68.2 ± 10.3 70.5 ± 10.0 0.65
Male 26 (55) 33 (66) 35 (71) 35 (71) 0.31
Hypertension 38 (81) 37 (74) 48 (98) 48 (98) <0.01
Diabetes mellitus 20 (43) 20 (40) 29 (59) 23 (47) 0.23
Smoking 23 (49) 29 (58) 30 (61) 28 (57) 0.66
Dyslipidemia 35 (74) 33 (66) 35 (71) 43 (88) 0.06
Body mass index (kg/m2) 22.2 ± 2.5 22.4 ± 5.7 22.7 ± 5.4 22.7 ± 3.5 0.95
Proteinuria (g/day) 1.2 (0.1-3.3) 0.7 (0.1-2.6) 2.2 (0.4-4.0) 1.2 (0.4-3.6) 0.14
C-reactive protein (mg/dL) 0.05 (0.02-0.12) 0.09 (0.03-0.22) 0.13 (0.05-0.26) 0.09 (0.05-0.35)* 0.01
Hemoglobin (g/dL) 11.5 ± 2.2 11.1 ± 2.1 10.6 ± 2.0 9.6 ± 1.7** <0.01
Serum corrected calcium (mg/dL) 9.5 ± 0.6 9.4 ± 0.5 9.5 ± 0.5 9.3 ± 0.6 0.19
Serum phosphorus (mg/dL) 3.4 ± 0.5 3.5 ± 0.6 3.6 ± 0.5 4.4 ± 0.9** <0.01
Ca-P product (mg2/dL2) 32.5 ± 5.6 33.3 ± 6.0 34.4 ± 4.2 40.7 ± 8.5** <0.01
eGFR (ml/min/1.73m2) 46.9 (27.0-68.9) 33.6 (17.3-57.9) 22.0 (16.0-35.0)** 12.7 (9.0-17.2)** <0.01
CAAC 23 (49) 29 (58) 37 (76) 39 (80) <0.01

Values are expressed as the means ± SD, number (percent), or median (interquartile range).

CKD chronic kidney disease, FGF fibroblast growth factor, Ca-P calcium-phosphorus, eGFR estimated glomerular filtration rate, CAAC carotid artery calcification.

*p < 0.05, **p < 0.01 vs. FGF23-Quartile 1.

Nakayama et al.

Nakayama et al. BMC Nephrology 2013 14:22   doi:10.1186/1471-2369-14-22

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