Table 1

Differential diagnosis of hyponatremia
Hyponatremia
Hypervolemic Euvolemic Hypovolemic
TBW ++ + + + - _
TBNa + N N N - -
Urine Na - + N/+ - - -
Urine Osm + + + - + +
Edema + - - - - -
BP - N N N - -
Diuresis -/N -/N N + _ +
Possible diagnoses CHF SIAD Drugs Primary Polydipsia NON renal Losses: Renal Losses:
Cirrhosis Nausea Diuretics
Nephrotic Syn. Addison Vomiting C/RSWS
Diarrhea
Sweating

TBW: Total Body Water, TBNa: Total Body Sodium, BP: Blood Pressure, CHF: Chronic Heart Failure,

SIAD: Syndrome of Inappropriate Antidiuresis, C/RSWS: Cerebral Renal Salt Wasting Syndrome. N: Normal, +:elevated, -: reduced.

Corradetti et al.

Corradetti et al. BMC Nephrology 2013 14:140   doi:10.1186/1471-2369-14-140

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