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Open Access Highly Accessed Open Badges Research article

Do oral aluminium phosphate binders cause accumulation of aluminium to toxic levels?

Ruth Pepper, Neil Campbell, Magdi M Yaqoob, Norman B Roberts and Stanley L-S Fan*

BMC Nephrology 2011, 12:55  doi:10.1186/1471-2369-12-55

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Caution required in advocating a return to Al-based phosphate binders

Chris Exley   (2012-06-18 14:54)  Keele University email

Serum Al is not as good an indicator of the body burden of Al as urinary excretion of Al, either 24h or spot tests. Serum Al 48h post administration of DFO is at the very best an hopeful estimate of body burden of Al. Urine Al, 24h if possible, should have been measured in this study to obtain a better understanding of whether significant Al was absorbed across the gut following the use of an Al-based phosphate binder.
Caution is required before using the results of this study to advocate a return to Al-based phosphate binders in HD patients.

Competing interests

None declared


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