Open Access Research article

Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways

Panayiota Koupepidou1, Kyriacos N Felekkis1, Bettina Kränzlin2, Carsten Sticht2, Norbert Gretz2 and Constantinos Deltas1*

  • * Corresponding author: Constantinos Deltas deltas@ucy.ac.cy

  • † Equal contributors

Author Affiliations

1 Department of Biological Sciences, University of Cyprus

2 Medical Research Center, University of Heidelberg, Mannheim, Germany

For all author emails, please log on.

BMC Nephrology 2010, 11:23  doi:10.1186/1471-2369-11-23

Published: 2 September 2010

Additional files

Additional file 1:

List of selected gene categories and results obtained of the genome-wide expression analysis of whole kidney homogenates from 0, 6 and 24 day old transgenic rats PKD2 (1-703) (Mut) compared to whole kidneys isolated from SD rats (SD). The tables S1-S9 (Additional file 1) contain list of differentially expressed genes and the results obtained after statistical evaluation of the genome-wide expression analysis of whole kidney homogenates from 0, 6 and 24 day old transgenic rats PKD2 (1-703) (Mut) compared to whole kidneys isolated from SD rats (SD). Data were considered significant if the negative log of the p-value of Mut/SD was greater than 5.83. '*' denotes statistical significance after Bonferroni correction. The tables depict the following: Table S1- List of the cell-cycle genes. Table S2- List of the renin angiotensin system genes. Table S3- List of the focal adhesion pathway genes. Table S4- List of the Wnt signaling pathway genes. Table S5- List of the glutathione metabolism pathway genes. Table S6- List of the basal transcription factors genes. Table S7- List of the chronic myeloid leukemia pathway genes. Table S8- List of the metabolism of xenobiotics by cytochrome P450 pathway genes. Table S9- List of all differentially expressed genes

Format: DOC Size: 2.1MB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data