Table 1 |
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Quantitative micro-CT measurements |
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C57/BL mouse (Controls) |
ApoE-/-/LDL-/- double knockout mouse |
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Total Vascular Volume Fraction (mm3) |
4.3 ± 0.4 |
3.2 ± 0.3* |
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Venous Vascular Volume Fraction (mm3) |
3.9 ± 0.3 |
2.9 ± 0.4* |
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Arterial Vascular Volume Fraction (mm3) |
0.4 ± 0.1 |
0.3 ± 0.1 |
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Maximum Kidney Dimension (mm) |
10.6 ± 1.7 |
11.5 ± 1.9 |
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Number of Glomeruli (per cross-section) |
17 ± 3 |
24 ± 5* |
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Number of Diseased Glomeruli (per cross-section |
0 |
11 ± 3* |
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Glomeruli cross-sectional surface area (μm2) |
3533 ± 358 |
9959 ± 658* |
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Diameter Glomerular Capillaries (μm) |
8.2 ± 2.3 |
22.3 ± 3.9* |
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A significant decrease in the total vascular volume fraction and a significant increase in the total number and area of glomeruli is present in apoE-/-/LDL-/- double knockout mice compared to controls (*p < 0.001). The decrease of the total vascular volume fraction is due to the decrease in the venous vascular volume fraction (p < 0.01). No significant difference in the arterial vascular volume fraction was found between the groups (p < 0.4). |
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Langheinrich et al. BMC Nephrology 2010 11:18 doi:10.1186/1471-2369-11-18 |
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