Table 1

Animal models of proteinuria

Models

Proteinuria

Na handling

Ref

Injection of PAN

Sprague Dawley rat

10 g/mmol creat

Ascites, edema

[9]

90 mg/mg creat

Ascites, edema

[9]

3 g/24 h/kg body wt

Ascites, edema

[9]

30 mg/ml

Ascites, edema

[9]

Wild type B6/D2 mouse

0.03 mg/mg creat

[29]

ApoE^-/- mouse

0.2 mg/ml

[30]

Cox2 tg mouse

0.07 mg/mg creat

[29]

PRO/Re mouse

0.7 g/24 h/kg body wt

[31]

Injection of adriamycin

Sprague Dawley rat

25 mg/mg creat

Na retention

[9]

B6/D2 mouse

0.04 mg/mg creat

[41]

Balb/c mouse

23 mg/mg creat

[42]

Balb/c mouse

226 mg/mg creat

[43]

129 mouse

120 mg/mg creat

Ascites

[44]

Genetically modified mice

Laminin α5^-/-

200 mg/mg creat

[32]

Laminin β2^-/-

12 mg/ml

[33]

α-actinin-4^-/-

+ +

[34]

Nphs2^-/-

+ + +

HTA

[36]

CD2-AP^-/-

+ + +

[35]

CD151^-/-

+ + +

Edema

[27]

Human CD34⁺ engraftment

NOD/SCID mouse

0.04 mg/mg creat

[37]

Proteinuria in PAN nephrotic rats is given as a function of the different units found in the literature. + + and + + + refers to increases in proteinuria as determined by western blotting. When available, functional data related to renal sodium handling are provided; HTA, hypertension.

Brideau and Doucet BMC Nephrology 2010 11:15   doi:10.1186/1471-2369-11-15