Table 3

Association of SREBP-2 gene polymorphisms between the AVN subgroup patients and controls
Loci
 Sub-group
 Genotype
Allele 2 vs. 1
 Codominant Heterozy
 Dominant
 Recessive













11
 12
 22
 MAF

(11 vs 12 vs 22)*
 12 + 22 vs. 11
 22 vs. 11 + 12












OR (95% CI)
 P†
 OR (95% CI)
 P†
 OR (95% CI)
 P†
 OR (95% CI)
 P†


TT
 CT
 CC



















IVS1+8408 T>C
 Alc
 74
 102
 30
 0.393
 0.764
(0.581–1.004)
 0.054
 0.759
(0.575–1.002)
 0.052
 0.744
(0.494–1.121)
 0.157
 0.629
(0.379–1.045)
 0.073
(rs2267439)
 Idio
 69
 85
 27
 0.384
 0.701
(0.532–0.923)
 0.011
 0.695
(0.525–0.920)
 0.011
 0.625
(0.417–0.937)
 0.023
 0.617
(0.368–1.034)
 0.067

Ster
 16
 31
 9
 0.438
 0.865
(0.560–1.335)
 0.511
 0.860
(0.553–1.339)
 0.504
 0.940
(0.479–1.844)
 0.857
 0.677
(0.301–1.523)
 0.346


GG
 GT
 TT



















IVS3-342 G>T
 Alc
 115
 74
 16
 0.259
 1.017
(0.747–1.386)
 0.914
 1.016
(0.751–1.375)
 0.916
 1.021
(0.694–1.501)
 0.917
 1.022
(0.495–2.109)
 0.954
(rs2269657)
 Idio
 94
 73
 14
 0.279
 1.159
(0.855–1.570)
 0.342
 1.165
(0.855–1.589)
 0.333
 1.153
(0.785–1.695)
 0.468
 1.431
(0.675–3.030)
 0.350

Ster
 32
 20
 2
 0.222
 0.951
(0.568–1.592)
 0.848
 0.949
(0.561–1.604)
 0.845
 0.989
(0.527–1.858)
 0.973
 0.704
(0.150–3.297)
 0.656


GG
 AG
 AA



















IVS11+414 G>A
 Alc
 95
 84
 25
 0.328
 1.241
(0.925–1.665)
 0.150
 1.244
(0.925–1.672)
 0.149
 1.143
(0.779–1.678)
 0.493
 2.037
(1.028–4.034)
 0.041
(rs1052717)
 Idio
 85
 72
 24
 0.332
 1.214
(0.910–1.621)
 0.188
 1.214
(0.909–1.621)
 0.189
 1.092
(0.747–1.598)
 0.649
 1.998
(1.055–3.783)
 0.034

Ster
 22
 30
 4
 0.339
 1.230
(0.778–1.945)
 0.376
 1.258
(0.775–2.042)
 0.352
 1.452
(0.782–2.695)
 0.237
 0.966
(0.295–3.163)
 0.954













GG
 AG
 AA








IVS12-1667 G>A
 Alc
 74
 95
 30
 0.389
 1.380
(1.036–1.837)
 0.027
 1.382
(1.036–1.844)
 0.028
 1.495
(1.007–2.220)
 0.046
 1.575
(0.877–2.828)
 0.128
(rs2267443)
 Idio
 73
 71
 31
 0.380
 1.236
(0.930–1.642)
 0.144
 1.226
(0.927–1.620)
 0.153
 1.126
(0.759–1.669)
 0.556
 1.763
(1.015–3.059)
 0.044

Ster
 22
 26
 8
 0.375
 1.334
0.849–2.094)
 0.211
 1.340
(0.849–2.114)
 0.209
 1.408
(0.749–2.647)
 0.288
 0.566
(0.637–3.852)
 0.328

*11: homozygotes for the major allele, 12: heterozygotes and 22: homozygotes for the minor allele.

† Logistic regression analyses were used for calculating. bold: P value < 0.05

Kim et al. BMC Medical Genetics 2008 9:94   doi:10.1186/1471-2350-9-94